Autonomic and cognitive function response to normobaric hyperoxia exposure in healthy subjects. Preliminary study
<p><strong>Background and objective:</strong> This is the first study to investigate the effect of high-flow oxygen therapy, using a normobaric chamber on cognitive, biochemical (oxidative stress parameters and the level of neurotrophins), cardiovascular and autonomic functioning.&...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2020
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| _version_ | 1797097690838859776 |
|---|---|
| author | Kujawski, S Słomko, J Morten, KJ Murovska, M Buszko, K Newton, JL Zalewski, P |
| author_facet | Kujawski, S Słomko, J Morten, KJ Murovska, M Buszko, K Newton, JL Zalewski, P |
| author_sort | Kujawski, S |
| collection | OXFORD |
| description | <p><strong>Background and objective:</strong> This is the first study to investigate the effect of high-flow oxygen therapy, using a normobaric chamber on cognitive, biochemical (oxidative stress parameters and the level of neurotrophins), cardiovascular and autonomic functioning.</p>
<p><strong>Materials and methods:</strong> 17 healthy volunteers, eight males and nine females, with a mean age of 37.5 years, were examined. The experimental study involved ten two-hour exposures in a normobaric chamber with a total pressure of 1500 hPa, in air adjusted to 37% oxygen, 1.079% carbon dioxide and 0.44% hydrogen. Cognitive function was assessed by using Trail Making Test parts A, B and difference in results of these tests (TMT A, TMT B and TMT B-A); California Verbal Learning Test (CVLT); Digit symbol substitution test (DSST); and Digit Span (DS). Fatigue (Fatigue Severity Scale (FSS)), cardiovascular, autonomic and baroreceptor functioning (Task Force Monitor) and biochemical parameters were measured before and after intervention.</p>
<p><strong>Results:</strong> After 10 sessions in the normobaric chamber, significant decreases in weight, caused mainly by body fat % decrease (24.86 vs. 23.93%, p = 0.04 were observed. TMT part A and B results improved (p = 0.0007 and p = 0.001, respectively). In contrast, there was no statistically significant influence on TMT B-A. Moreover, decrease in the number of symbols left after a one-minute test in DSST was noted (p = 0.0001). The mean number of words correctly recalled in the CVLT Long Delay Free Recall test improved (p = 0.002), and a reduction in fatigue was observed (p = 0.001). Biochemical tests showed a reduction in levels of malondialdehyde (p < 0.001), with increased levels of Cu Zn superoxide dismutase (p < 0.001), Neurotrophin 4 (p = 0.0001) and brain-derived neurotrophic factor (p = 0.001). A significant increase in nitric oxide synthase 2 (Z = 2.29, p = 0.02) and Club cell secretory protein (p = 0.015) was also noted. Baroreceptor function was significantly improved after normobaric exposures (p = 0.003). Significant effect of normobaric exposures and BDNF in CVLT Long Delay Free Recall was noted.</p>
<p><strong>Conclusions:</strong> This study demonstrates that 10 exposures in a normobaric chamber have a positive impact on visual information and set-shifting processing speed and increase auditory-verbal short-term memory, neurotrophic levels and baroreceptor function. A response of the respiratory tract to oxidative stress was also noted. There is a need to rigorously examine the safety of normobaric therapy. Further studies should be carried out with physician examination, both pre and post treatment.</p> |
| first_indexed | 2024-03-07T04:59:06Z |
| format | Journal article |
| id | oxford-uuid:d7a62f3f-b214-411a-bdec-ad717eeb47f2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:59:06Z |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:d7a62f3f-b214-411a-bdec-ad717eeb47f22022-03-27T08:42:38ZAutonomic and cognitive function response to normobaric hyperoxia exposure in healthy subjects. Preliminary studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d7a62f3f-b214-411a-bdec-ad717eeb47f2EnglishSymplectic ElementsMDPI2020Kujawski, SSłomko, JMorten, KJMurovska, MBuszko, KNewton, JLZalewski, P<p><strong>Background and objective:</strong> This is the first study to investigate the effect of high-flow oxygen therapy, using a normobaric chamber on cognitive, biochemical (oxidative stress parameters and the level of neurotrophins), cardiovascular and autonomic functioning.</p> <p><strong>Materials and methods:</strong> 17 healthy volunteers, eight males and nine females, with a mean age of 37.5 years, were examined. The experimental study involved ten two-hour exposures in a normobaric chamber with a total pressure of 1500 hPa, in air adjusted to 37% oxygen, 1.079% carbon dioxide and 0.44% hydrogen. Cognitive function was assessed by using Trail Making Test parts A, B and difference in results of these tests (TMT A, TMT B and TMT B-A); California Verbal Learning Test (CVLT); Digit symbol substitution test (DSST); and Digit Span (DS). Fatigue (Fatigue Severity Scale (FSS)), cardiovascular, autonomic and baroreceptor functioning (Task Force Monitor) and biochemical parameters were measured before and after intervention.</p> <p><strong>Results:</strong> After 10 sessions in the normobaric chamber, significant decreases in weight, caused mainly by body fat % decrease (24.86 vs. 23.93%, p = 0.04 were observed. TMT part A and B results improved (p = 0.0007 and p = 0.001, respectively). In contrast, there was no statistically significant influence on TMT B-A. Moreover, decrease in the number of symbols left after a one-minute test in DSST was noted (p = 0.0001). The mean number of words correctly recalled in the CVLT Long Delay Free Recall test improved (p = 0.002), and a reduction in fatigue was observed (p = 0.001). Biochemical tests showed a reduction in levels of malondialdehyde (p < 0.001), with increased levels of Cu Zn superoxide dismutase (p < 0.001), Neurotrophin 4 (p = 0.0001) and brain-derived neurotrophic factor (p = 0.001). A significant increase in nitric oxide synthase 2 (Z = 2.29, p = 0.02) and Club cell secretory protein (p = 0.015) was also noted. Baroreceptor function was significantly improved after normobaric exposures (p = 0.003). Significant effect of normobaric exposures and BDNF in CVLT Long Delay Free Recall was noted.</p> <p><strong>Conclusions:</strong> This study demonstrates that 10 exposures in a normobaric chamber have a positive impact on visual information and set-shifting processing speed and increase auditory-verbal short-term memory, neurotrophic levels and baroreceptor function. A response of the respiratory tract to oxidative stress was also noted. There is a need to rigorously examine the safety of normobaric therapy. Further studies should be carried out with physician examination, both pre and post treatment.</p> |
| spellingShingle | Kujawski, S Słomko, J Morten, KJ Murovska, M Buszko, K Newton, JL Zalewski, P Autonomic and cognitive function response to normobaric hyperoxia exposure in healthy subjects. Preliminary study |
| title | Autonomic and cognitive function response to normobaric hyperoxia exposure in healthy subjects. Preliminary study |
| title_full | Autonomic and cognitive function response to normobaric hyperoxia exposure in healthy subjects. Preliminary study |
| title_fullStr | Autonomic and cognitive function response to normobaric hyperoxia exposure in healthy subjects. Preliminary study |
| title_full_unstemmed | Autonomic and cognitive function response to normobaric hyperoxia exposure in healthy subjects. Preliminary study |
| title_short | Autonomic and cognitive function response to normobaric hyperoxia exposure in healthy subjects. Preliminary study |
| title_sort | autonomic and cognitive function response to normobaric hyperoxia exposure in healthy subjects preliminary study |
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