Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients.
BACKGROUND: Animal experimental studies suggest that the amino acid valine may decrease brain serotonin (5-HT) function by inhibiting the transport of the 5-HT precursor, L-tryptophan, across the blood barrier. The aim of the present study was to assess whether valine could decrease brain 5-HT funct...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1995
|
| _version_ | 1797097694055890944 |
|---|---|
| author | Williamson, D McTavish, S Park, S Cowen, P |
| author_facet | Williamson, D McTavish, S Park, S Cowen, P |
| author_sort | Williamson, D |
| collection | OXFORD |
| description | BACKGROUND: Animal experimental studies suggest that the amino acid valine may decrease brain serotonin (5-HT) function by inhibiting the transport of the 5-HT precursor, L-tryptophan, across the blood barrier. The aim of the present study was to assess whether valine could decrease brain 5-HT function in healthy subjects and provoke symptomatic relapse in recently remitted depressed patients taking antidepressant drug treatment. METHOD: We studied the effect of valine (30 g) on the prolactin (PRL) response to the 5-HT releasing agent, D-fenfluramine, in healthy male subjects and on the mood of 12 remitted depressed patients taking either selective serotonin re-uptake inhibitors (n = 10) or lithium and amitriptyline (n = 2). RESULTS: Valine significantly lowered the PRL response to D-fenfluramine in healthy subjects. In the remitted depressives, valine caused a mild but detectable lowering of mood on a number of measures but only one patient experienced a significant relapse in mood. CONCLUSIONS: Valine administration may decrease brain 5-HT neurotransmission in humans. This effect could explain the mild increase in depressive symptoms in patients taking 5-HT-potentiating drugs. |
| first_indexed | 2024-03-07T04:59:09Z |
| format | Journal article |
| id | oxford-uuid:d7aa80c5-c1ec-4ac4-9815-b99d631a5605 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:59:09Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:d7aa80c5-c1ec-4ac4-9815-b99d631a56052022-03-27T08:42:41ZEffect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d7aa80c5-c1ec-4ac4-9815-b99d631a5605EnglishSymplectic Elements at Oxford1995Williamson, DMcTavish, SPark, SCowen, PBACKGROUND: Animal experimental studies suggest that the amino acid valine may decrease brain serotonin (5-HT) function by inhibiting the transport of the 5-HT precursor, L-tryptophan, across the blood barrier. The aim of the present study was to assess whether valine could decrease brain 5-HT function in healthy subjects and provoke symptomatic relapse in recently remitted depressed patients taking antidepressant drug treatment. METHOD: We studied the effect of valine (30 g) on the prolactin (PRL) response to the 5-HT releasing agent, D-fenfluramine, in healthy male subjects and on the mood of 12 remitted depressed patients taking either selective serotonin re-uptake inhibitors (n = 10) or lithium and amitriptyline (n = 2). RESULTS: Valine significantly lowered the PRL response to D-fenfluramine in healthy subjects. In the remitted depressives, valine caused a mild but detectable lowering of mood on a number of measures but only one patient experienced a significant relapse in mood. CONCLUSIONS: Valine administration may decrease brain 5-HT neurotransmission in humans. This effect could explain the mild increase in depressive symptoms in patients taking 5-HT-potentiating drugs. |
| spellingShingle | Williamson, D McTavish, S Park, S Cowen, P Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients. |
| title | Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients. |
| title_full | Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients. |
| title_fullStr | Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients. |
| title_full_unstemmed | Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients. |
| title_short | Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients. |
| title_sort | effect of valine on 5 ht mediated prolactin release in healthy volunteers and on mood in remitted depressed patients |
| work_keys_str_mv | AT williamsond effectofvalineon5htmediatedprolactinreleaseinhealthyvolunteersandonmoodinremitteddepressedpatients AT mctavishs effectofvalineon5htmediatedprolactinreleaseinhealthyvolunteersandonmoodinremitteddepressedpatients AT parks effectofvalineon5htmediatedprolactinreleaseinhealthyvolunteersandonmoodinremitteddepressedpatients AT cowenp effectofvalineon5htmediatedprolactinreleaseinhealthyvolunteersandonmoodinremitteddepressedpatients |