Lineage-restricted regulation of SCD and fatty acid saturation by MITF controls melanoma phenotypic plasticity

Lineage-restricted regulation of SCD and fatty acid saturation by MITF controls melanoma phenotypic plasticity

Phenotypic and metabolic heterogeneity within tumors is a major barrier to effective cancer therapy. How metabolism is implicated in specific phenotypes and whether lineage-restricted mechanisms control key metabolic vulnerabilities remain poorly understood. In melanoma, downregulation of the lineag...

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Príomhchruthaitheoirí: Vivas-García, Y, Falletta, P, Liebing, J, Louphrasitthiphol, P, Feng, Y, Chauhan, J, Scott, D, Glodde, N, Chocarro-Calvo, A, Bonham, S, Osterman, A, Fischer, R, Ronai, Z, García-Jiménez, C, Hölzel, M, Goding, C
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Cell Press 2019

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