TSG-6 modulates the interaction between hyaluronan and cell surface CD44.

Interactions between CD44 and hyaluronan are implicated in the primary adhesion of lymphocytes to endothelium at inflammatory locations. Here we show that preincubation of hyaluronan with full-length recombinant TSG-6 or its Link module domain (Link_TSG6) enhances or induces the binding of hyalurona...

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Autors principals: Lesley, J, Gál, I, Mahoney, D, Cordell, MR, Rugg, MS, Hyman, R, Day, A, Mikecz, K
Format: Journal article
Idioma:English
Publicat: 2004