Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya.
Neonatal jaundice (NJ) and sepsis are common causes of neonatal mortality in sub-Saharan Africa, but little is known about the long-term morbidity in this setting. This study aimed to describe the neurological and developmental sequelae of severe neonatal hyperbilirubinaemia and neonatal sepsis (NS)...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2005
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| _version_ | 1797097756694675456 |
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| author | Gordon, A English, M Tumaini Dzombo, J Karisa, M Newton, C |
| author_facet | Gordon, A English, M Tumaini Dzombo, J Karisa, M Newton, C |
| author_sort | Gordon, A |
| collection | OXFORD |
| description | Neonatal jaundice (NJ) and sepsis are common causes of neonatal mortality in sub-Saharan Africa, but little is known about the long-term morbidity in this setting. This study aimed to describe the neurological and developmental sequelae of severe neonatal hyperbilirubinaemia and neonatal sepsis (NS) in a district hospital in rural Kenya. Twenty-three term infants with NJ [total serum bilirubin (TSB) >300 mumol/l] and 24 infants with a history of NS were identified from hospital records. These children were compared to 40 children from the community (CC) without neonatal problems. At ages 18-32 months, the children's neurological, motor and developmental status were assessed, and blood groups of the NJ and NS subjects and their mothers were determined. Ten (43%) of the NJ subjects were unable to sit and/or stand independently. The NJ subjects had significantly more neurological, motor and developmental difficulties and caused greater maternal concern than the CCs. Five (21%) of the NJ subjects had possible blood group incompatibility. The NS subjects had significantly more motor and eye-hand difficulties and maternal concerns expressed than the CCs. Severe NJ in term infants (of mainly non-haemolytic origin) was associated with a high prevalence of neurological and developmental sequelae at ages 18-32 months. The NS is also associated with neuro-developmental sequelae, but the pattern is different to those seen in NJ. Since NS is common in resource poor countries, this may be an important cause of neuro-developmental impairment in children living in this setting. |
| first_indexed | 2024-03-07T04:59:48Z |
| format | Journal article |
| id | oxford-uuid:d7e483f1-14b8-45ac-85c8-25daa057cf7d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:59:48Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:d7e483f1-14b8-45ac-85c8-25daa057cf7d2022-03-27T08:44:16ZNeurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d7e483f1-14b8-45ac-85c8-25daa057cf7dEnglishSymplectic Elements at Oxford2005Gordon, AEnglish, MTumaini Dzombo, JKarisa, MNewton, CNeonatal jaundice (NJ) and sepsis are common causes of neonatal mortality in sub-Saharan Africa, but little is known about the long-term morbidity in this setting. This study aimed to describe the neurological and developmental sequelae of severe neonatal hyperbilirubinaemia and neonatal sepsis (NS) in a district hospital in rural Kenya. Twenty-three term infants with NJ [total serum bilirubin (TSB) >300 mumol/l] and 24 infants with a history of NS were identified from hospital records. These children were compared to 40 children from the community (CC) without neonatal problems. At ages 18-32 months, the children's neurological, motor and developmental status were assessed, and blood groups of the NJ and NS subjects and their mothers were determined. Ten (43%) of the NJ subjects were unable to sit and/or stand independently. The NJ subjects had significantly more neurological, motor and developmental difficulties and caused greater maternal concern than the CCs. Five (21%) of the NJ subjects had possible blood group incompatibility. The NS subjects had significantly more motor and eye-hand difficulties and maternal concerns expressed than the CCs. Severe NJ in term infants (of mainly non-haemolytic origin) was associated with a high prevalence of neurological and developmental sequelae at ages 18-32 months. The NS is also associated with neuro-developmental sequelae, but the pattern is different to those seen in NJ. Since NS is common in resource poor countries, this may be an important cause of neuro-developmental impairment in children living in this setting. |
| spellingShingle | Gordon, A English, M Tumaini Dzombo, J Karisa, M Newton, C Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. |
| title | Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. |
| title_full | Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. |
| title_fullStr | Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. |
| title_full_unstemmed | Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. |
| title_short | Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. |
| title_sort | neurological and developmental outcome of neonatal jaundice and sepsis in rural kenya |
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