Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.

Rap1 is a small GTPase that modulates adhesion of T cells by regulating inside-out signaling through LFA-1. The bulk of Rap1 is expressed in a GDP-bound state on intracellular vesicles. Exocytosis of these vesicles delivers Rap1 to the plasma membrane, where it becomes activated. We report here that...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Mor, A, Wynne, J, Ahearn, I, Dustin, M, Du, G, Philips, MR
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 2009