An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.

During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract (OFT) morphology. In th...

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Bibliographic Details
Main Authors: Prall, O, Menon, M, Solloway, M, Watanabe, Y, Zaffran, S, Bajolle, F, Biben, C, McBride, J, Robertson, B, Chaulet, H, Stennard, F, Wise, N, Schaft, D, Wolstein, O, Furtado, M, Shiratori, H, Chien, K, Hamada, H, Black, B, Saga, Y, Robertson, E, Buckingham, M, Harvey, R
Format: Journal article
Language:English
Published: 2007

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