An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.

During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract (OFT) morphology. In th...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Prall, O, Menon, M, Solloway, M, Watanabe, Y, Zaffran, S, Bajolle, F, Biben, C, McBride, J, Robertson, B, Chaulet, H, Stennard, F, Wise, N, Schaft, D, Wolstein, O, Furtado, M, Shiratori, H, Chien, K, Hamada, H, Black, B, Saga, Y, Robertson, E, Buckingham, M, Harvey, R
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2007

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gan: Furtado, M, et al.
Cyhoeddwyd: (2005)

Mice lacking Bmp6 function.
gan: Solloway, M, et al.
Cyhoeddwyd: (1998)

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gan: Mommersteeg, M, et al.
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gan: Peterkin, T, et al.
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Cyhoeddwyd: (2006)

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gan: Randall F Ankeny, et al.
Cyhoeddwyd: (2011-01-01)

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gan: Rubens Sautchuk, et al.
Cyhoeddwyd: (2022-05-01)

Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.
gan: Arnold, S, et al.
Cyhoeddwyd: (2006)

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Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury.
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gan: Dunn, N, et al.
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ActRIIA and BMPRII Type II BMP receptor subunits selectively required for Smad4-independent BMP7-evoked chemotaxis.
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