Nuclear factories for replication, transcription and repair
Recent experiments suggest that the active polymerases involved in replication, transcription and the repair of damage in DNA are concentrated in large structures - 'factories' - within eukaryotic nuclei. This has forced us to reevaluate how polymerases work. The traditional view involved...
| Main Authors: | , , , , , , |
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| Format: | Conference item |
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1995
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| _version_ | 1797097783579115520 |
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| author | McManus, J Hughes, T Pombo, A Jones, E Iborra, F Jackson, D Cook, P |
| author_facet | McManus, J Hughes, T Pombo, A Jones, E Iborra, F Jackson, D Cook, P |
| author_sort | McManus, J |
| collection | OXFORD |
| description | Recent experiments suggest that the active polymerases involved in replication, transcription and the repair of damage in DNA are concentrated in large structures - 'factories' - within eukaryotic nuclei. This has forced us to reevaluate how polymerases work. The traditional view involved enzymes that tracked along templates and this was sensible if the polymerases were small relative to the templates and if they acted alone. However, immobilization of many polymerases within one factory means that the templates must move instead. Then the position of a gene in three-dimensional space relative to a factory will dictate how easily replication, transcription and repair can occur. |
| first_indexed | 2024-03-07T05:00:11Z |
| format | Conference item |
| id | oxford-uuid:d8019d42-55bb-4cad-bbbb-f20e2e723bb9 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:00:11Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:d8019d42-55bb-4cad-bbbb-f20e2e723bb92022-03-27T08:45:12ZNuclear factories for replication, transcription and repairConference itemhttp://purl.org/coar/resource_type/c_5794uuid:d8019d42-55bb-4cad-bbbb-f20e2e723bb9Symplectic Elements at Oxford1995McManus, JHughes, TPombo, AJones, EIborra, FJackson, DCook, PRecent experiments suggest that the active polymerases involved in replication, transcription and the repair of damage in DNA are concentrated in large structures - 'factories' - within eukaryotic nuclei. This has forced us to reevaluate how polymerases work. The traditional view involved enzymes that tracked along templates and this was sensible if the polymerases were small relative to the templates and if they acted alone. However, immobilization of many polymerases within one factory means that the templates must move instead. Then the position of a gene in three-dimensional space relative to a factory will dictate how easily replication, transcription and repair can occur. |
| spellingShingle | McManus, J Hughes, T Pombo, A Jones, E Iborra, F Jackson, D Cook, P Nuclear factories for replication, transcription and repair |
| title | Nuclear factories for replication, transcription and repair |
| title_full | Nuclear factories for replication, transcription and repair |
| title_fullStr | Nuclear factories for replication, transcription and repair |
| title_full_unstemmed | Nuclear factories for replication, transcription and repair |
| title_short | Nuclear factories for replication, transcription and repair |
| title_sort | nuclear factories for replication transcription and repair |
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