Characterization of a novel IncHI2 plasmid carrying tandem copies of blaCTX-M-2 in a fosA6-harboring Escherichia coli ST410 strain
Extended-spectrum β-lactamase gene blaCTX-M-2 is mainly associated with ISCR1 embedded in complex sul1-type integrons, but information on the genetic context of plasmids harboring the ISCR1-blaCTX-M-2module remains limited. In this study, a blaCTX-M-2-harboring plasmid pYD786-1 belonging to novel ST...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Society for Microbiology
2016
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| _version_ | 1826299352204705792 |
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| author | Guo, Q Ding, B Jové, T Stoesser, N Cooper, V Wang, M Doi, Y |
| author_facet | Guo, Q Ding, B Jové, T Stoesser, N Cooper, V Wang, M Doi, Y |
| author_sort | Guo, Q |
| collection | OXFORD |
| description | Extended-spectrum β-lactamase gene blaCTX-M-2 is mainly associated with ISCR1 embedded in complex sul1-type integrons, but information on the genetic context of plasmids harboring the ISCR1-blaCTX-M-2module remains limited. In this study, a blaCTX-M-2-harboring plasmid pYD786-1 belonging to novel ST2-IncHI2 was sequenced and analyzed from an Escherichia coli ST410 clinical strain. pYD786-1 belonged to APEC-O1-R type IncHI2 plasmids which are widely distributed in human, poultry and livestock strains. It contained a multidrug resistance mosaic region (MRR) consisting of Tn21::In2 transposon backbone augmented by acquisition of duplicated ISCR1-blaCTX-M-2 Tn2411, a Tn21::In2 precursor, likely played a role in the generation of the MRR in pN13-01290_23, the putative progenitor plasmid of pYD786-1 found in a foodborne Salmonella strain. Tn21/Tn2411::In::ISCR1-blaCTX-M-2 derivatives including pYD786-1 have been identified in strains from Europe, South America and the U.S., suggesting potential global dissemination of the blaCTX-M-2 modules mediated by this vehicle. |
| first_indexed | 2024-03-07T05:00:35Z |
| format | Journal article |
| id | oxford-uuid:d81f5089-f1d2-4084-bc2b-590d7ee6c26b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:00:35Z |
| publishDate | 2016 |
| publisher | American Society for Microbiology |
| record_format | dspace |
| spelling | oxford-uuid:d81f5089-f1d2-4084-bc2b-590d7ee6c26b2022-03-27T08:46:31ZCharacterization of a novel IncHI2 plasmid carrying tandem copies of blaCTX-M-2 in a fosA6-harboring Escherichia coli ST410 strainJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d81f5089-f1d2-4084-bc2b-590d7ee6c26bEnglishSymplectic Elements at OxfordAmerican Society for Microbiology2016Guo, QDing, BJové, TStoesser, NCooper, VWang, MDoi, YExtended-spectrum β-lactamase gene blaCTX-M-2 is mainly associated with ISCR1 embedded in complex sul1-type integrons, but information on the genetic context of plasmids harboring the ISCR1-blaCTX-M-2module remains limited. In this study, a blaCTX-M-2-harboring plasmid pYD786-1 belonging to novel ST2-IncHI2 was sequenced and analyzed from an Escherichia coli ST410 clinical strain. pYD786-1 belonged to APEC-O1-R type IncHI2 plasmids which are widely distributed in human, poultry and livestock strains. It contained a multidrug resistance mosaic region (MRR) consisting of Tn21::In2 transposon backbone augmented by acquisition of duplicated ISCR1-blaCTX-M-2 Tn2411, a Tn21::In2 precursor, likely played a role in the generation of the MRR in pN13-01290_23, the putative progenitor plasmid of pYD786-1 found in a foodborne Salmonella strain. Tn21/Tn2411::In::ISCR1-blaCTX-M-2 derivatives including pYD786-1 have been identified in strains from Europe, South America and the U.S., suggesting potential global dissemination of the blaCTX-M-2 modules mediated by this vehicle. |
| spellingShingle | Guo, Q Ding, B Jové, T Stoesser, N Cooper, V Wang, M Doi, Y Characterization of a novel IncHI2 plasmid carrying tandem copies of blaCTX-M-2 in a fosA6-harboring Escherichia coli ST410 strain |
| title | Characterization of a novel IncHI2 plasmid carrying tandem copies of blaCTX-M-2 in a fosA6-harboring Escherichia coli ST410 strain |
| title_full | Characterization of a novel IncHI2 plasmid carrying tandem copies of blaCTX-M-2 in a fosA6-harboring Escherichia coli ST410 strain |
| title_fullStr | Characterization of a novel IncHI2 plasmid carrying tandem copies of blaCTX-M-2 in a fosA6-harboring Escherichia coli ST410 strain |
| title_full_unstemmed | Characterization of a novel IncHI2 plasmid carrying tandem copies of blaCTX-M-2 in a fosA6-harboring Escherichia coli ST410 strain |
| title_short | Characterization of a novel IncHI2 plasmid carrying tandem copies of blaCTX-M-2 in a fosA6-harboring Escherichia coli ST410 strain |
| title_sort | characterization of a novel inchi2 plasmid carrying tandem copies of blactx m 2 in a fosa6 harboring escherichia coli st410 strain |
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