IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans

Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells,...

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書目詳細資料
Main Authors: Wellington, D, Yin, Z, Abdel-Haq, A, Zhang, L, Forbester, J, Kite, K, Rajapaksa, U, Laurenson-Schafer, H, Makvandi-Nejad, S, Jin, B, Bowes, E, Manoharan, K, Maldonado-Perez, D, Verrill, C, Humphreys, I, Dong, T
格式: Journal article
語言:English
出版: Wiley 2020
實物特徵
總結:Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells.