IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans
Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells,...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2020
|
| _version_ | 1826299372844875776 |
|---|---|
| author | Wellington, D Yin, Z Abdel-Haq, A Zhang, L Forbester, J Kite, K Rajapaksa, U Laurenson-Schafer, H Makvandi-Nejad, S Jin, B Bowes, E Manoharan, K Maldonado-Perez, D Verrill, C Humphreys, I Dong, T |
| author_facet | Wellington, D Yin, Z Abdel-Haq, A Zhang, L Forbester, J Kite, K Rajapaksa, U Laurenson-Schafer, H Makvandi-Nejad, S Jin, B Bowes, E Manoharan, K Maldonado-Perez, D Verrill, C Humphreys, I Dong, T |
| author_sort | Wellington, D |
| collection | OXFORD |
| description | Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells. |
| first_indexed | 2024-03-07T05:00:55Z |
| format | Journal article |
| id | oxford-uuid:d841f6f2-6189-4fe5-a41a-904c0be8fd7d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:00:55Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:d841f6f2-6189-4fe5-a41a-904c0be8fd7d2022-03-27T08:47:06ZIFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humansJournal articlehttp://purl.org/coar/resource_type/c_545buuid:d841f6f2-6189-4fe5-a41a-904c0be8fd7dEnglishSymplectic ElementsWiley2020Wellington, DYin, ZAbdel-Haq, AZhang, LForbester, JKite, KRajapaksa, ULaurenson-Schafer, HMakvandi-Nejad, SJin, BBowes, EManoharan, KMaldonado-Perez, DVerrill, CHumphreys, IDong, TUsing a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells. |
| spellingShingle | Wellington, D Yin, Z Abdel-Haq, A Zhang, L Forbester, J Kite, K Rajapaksa, U Laurenson-Schafer, H Makvandi-Nejad, S Jin, B Bowes, E Manoharan, K Maldonado-Perez, D Verrill, C Humphreys, I Dong, T IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_full | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_fullStr | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_full_unstemmed | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_short | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_sort | ifitm3 specific antibody reveals ifn preferences and slow ifn induction of the antiviral factor ifitm3 in humans |
| work_keys_str_mv | AT wellingtond ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT yinz ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT abdelhaqa ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT zhangl ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT forbesterj ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT kitek ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT rajapaksau ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT laurensonschaferh ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT makvandinejads ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT jinb ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT bowese ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT manoharank ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT maldonadoperezd ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT verrillc ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT humphreysi ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans AT dongt ifitm3specificantibodyrevealsifnpreferencesandslowifninductionoftheantiviralfactorifitm3inhumans |