Cytoplasmic expression systems triggered by mRNA yield increased gene expression in post-mitotic neurons

Cytoplasmic expression systems triggered by mRNA yield increased gene expression in post-mitotic neurons

Non-viral vectors are promising vehicles for gene therapy but delivery of plasmid DNA to post-mitotic cells is challenging as nuclear entry is particularly inefficient. We have developed and evaluated a hybrid mRNA/DNA system designed to bypass the nuclear barrier to transfection and facilitate cyto...

Descripció completa

Dades bibliogràfiques
Autors principals:	Farrow, P, Barrett, L, Stevenson, M, Fisher, K, Finn, J, Spice, R, Allan, M, Berry, M, Logan, A, Seymour, L, Read, M
Format:	Journal article
Idioma:	English
Publicat:	Oxford University Press 2006
Matèries:	Life Sciences

Ítems similars

A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids.
per: Read, M, et al.
Publicat: (2005)

Fasting induced cytoplasmic Fto expression in some neurons of rat hypothalamus.
per: Predrag Vujovic, et al.
Publicat: (2013-01-01)

PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression
per: Francesca R. Mariotti, et al.
Publicat: (2019-03-01)

Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells
per: Bettinger, T, et al.
Publicat: (2001)

Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells.
per: Bettinger, T, et al.
Publicat: (2001)

In vitro evaluation of a 'stealth' adenoviral vector for targeted gene delivery to adult mammalian neurones.
per: Sims, K, et al.
Publicat: (2009)

Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons
per: Nadine F. Joseph, et al.
Publicat: (2021-01-01)

Mitotic chromosomes scale to nuclear-cytoplasmic ratio and cell size in Xenopus
per: Coral Y Zhou, et al.
Publicat: (2023-04-01)

Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons
per: Amira Hassan, et al.
Publicat: (2020-04-01)

Adenosine Receptor mRNA Expression in Frontal Cortical Neurons in Schizophrenia
per: Smita Sahay, et al.
Publicat: (2023-12-01)

Cohesin Removal Reprograms Gene Expression upon Mitotic Entry
per: Perea-Resa, Carlos, et al.
Publicat: (2022)

Cohesin Removal Reprograms Gene Expression upon Mitotic Entry
per: Perea-Resa, Carlos, et al.
Publicat: (2021)

Increased cytoplasmic expression of PETase enzymes in E. coli
per: Luke M. Carter, et al.
Publicat: (2024-11-01)

The Dynamics of Cytoplasmic mRNA Metabolism
per: Eisen, Timothy J, et al.
Publicat: (2021)

Wolbachia superinfections and the expression of cytoplasmic incompatibility.
per: Sinkins, S, et al.
Publicat: (1995)

Epilepsy protein Efhc1/myoclonin1 is expressed in cells with motile cilia but not in neurons or mitotic apparatuses in brain
per: Toshimitsu Suzuki, et al.
Publicat: (2020-12-01)

MELK expression correlates with tumor mitotic activity but is not required for cancer growth
per: Christopher J Giuliano, et al.
Publicat: (2018-02-01)

Poliovirus 2A protease triggers a selective nucleo-cytoplasmic redistribution of splicing factors to regulate alternative pre-mRNA splicing.
per: Enrique Álvarez, et al.
Publicat: (2013-01-01)

Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus
per: Paola Bardetti, et al.
Publicat: (2019-10-01)

Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase.
per: Anaïs Estrada-Gelonch, et al.
Publicat: (2009-09-01)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma.
per: Nobumasa eMizuno, et al.
Publicat: (2013-09-01)

SBDS expression and localization at the mitotic spindle in human myeloid progenitors.
per: Claudia Orelio, et al.
Publicat: (2009-01-01)

Cytoplasmic polyadenylation in S. pombe
per: Stevenson, A, et al.
Publicat: (2005)

Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development.
per: Lin, A, et al.
Publicat: (2009)

Outside-in signaling through the major histocompatibility complex class-I cytoplasmic tail modulates glutamate receptor expression in neurons
per: Brett A. Eyford, et al.
Publicat: (2023-08-01)

Assessment of prognostic significance of cytoplasmic survivin expression in advanced oesophageal cancer.
per: G Wallner, et al.
Publicat: (2004-10-01)

Cytoplasmic Control of Sense-Antisense mRNA Pairs
per: Flore Sinturel, et al.
Publicat: (2015-09-01)

Self-assembling poly(l-lysine)/DNA complexes capable of integrin-mediated cellular uptake and gene expression
per: Carlisle, R, et al.
Publicat: (1999)

Robust trigger wave speed in Xenopus cytoplasmic extracts
per: Jo-Hsi Huang, et al.
Publicat: (2024-07-01)

Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress.
per: Akira Nishiyama, et al.
Publicat: (2012-01-01)

Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference.
per: Maria Patrizia Somma, et al.
Publicat: (2008-07-01)

CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons.
per: Christoph Straub, et al.
Publicat: (2014-01-01)

TET3-mediated accumulation of DNA hydroxymethylation contributes to the activity-dependent gene expression of Rab3a in post-mitotic neurons
per: Kun Luo, et al.
Publicat: (2021-09-01)

Metadherin mRNA expression in hepatocellular carcinoma
per: Nevein M. Al-sheikh, et al.
Publicat: (2018-10-01)

Transient focal ischemia triggers neuronal expression of GAT-3 in the rat perilesional cortex
per: Marcello Melone, et al.
Publicat: (2003-10-01)

The role of cytoplasmic mRNA polyadenylation in the pathogenesis of Osteogenesis imperfecta
per: Olga Gewartowska, et al.
Publicat: (2020-10-01)

Single mRNP Analysis Reveals that Small Cytoplasmic mRNP Granules Represent mRNA Singletons
per: Àngels Mateu-Regué, et al.
Publicat: (2019-10-01)

The Expression of Cytoplasmic Effectors by Phytophthora infestans in Potato Leaves and Tubers Is Organ-Biased
per: Aline Lacaze, et al.
Publicat: (2023-11-01)

Deoxynivalenol triggers mitotic catastrophe and apoptosis in C2C12 myoblasts
per: Zhenzhen Wang, et al.
Publicat: (2024-08-01)

Augmentation of Myc-Dependent Mitotic Gene Expression by the Pygopus2 Chromatin Effector
per: Phillip G.P. Andrews, et al.
Publicat: (2018-05-01)