Modelling and analysis of LRRK2 mutations in iPSC-derived dopaminergic neurons and astrocytes
<p>Parkinson's disease (PD) is a common neurodegenerative disorder, characterised by preferential loss of ventral midbrain dopaminergic (vmDA) neurons in the substantia nigra pars compacta (SNc). The majority of PD cases have unknown aetiology; however, between 5-10% arise due to known ge...
المؤلف الرئيسي: | Booth, H |
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مؤلفون آخرون: | Wade-Martins, R |
التنسيق: | أطروحة |
اللغة: | English |
منشور في: |
2017
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مواد مشابهة
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Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons
حسب: Andrew J. Schwab, وآخرون
منشور في: (2017-12-01) -
RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes
حسب: Booth, H, وآخرون
منشور في: (2019) -
The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease
حسب: Aurelie de Rus Jacquet, وآخرون
منشور في: (2021-09-01) -
Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons
حسب: Damien Meng-Kiat Leow, وآخرون
منشور في: (2024-06-01) -
Pro-maturational effects of human iPSC-derived cortical astrocytes upon iPSC-derived cortical neurons
حسب: Anne Hedegaard, وآخرون
منشور في: (2020)