Modelling and analysis of LRRK2 mutations in iPSC-derived dopaminergic neurons and astrocytes

<p>Parkinson's disease (PD) is a common neurodegenerative disorder, characterised by preferential loss of ventral midbrain dopaminergic (vmDA) neurons in the substantia nigra pars compacta (SNc). The majority of PD cases have unknown aetiology; however, between 5-10% arise due to known ge...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur: Booth, H
Awduron Eraill: Wade-Martins, R
Fformat: Traethawd Ymchwil
Iaith:English
Cyhoeddwyd: 2017