Functional connectomics from resting-state fMRI

Spontaneous fluctuations in activity in different parts of the brain can be used to study functional brain networks. We review the use of resting-state functional MRI (rfMRI) for the purpose of mapping the macroscopic functional connectome. After describing MRI acquisition and image-processing metho...

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Bibliographic Details
Main Authors: Smith, S, Vidaurre, D, Beckmann, C, Glasser, M, Jenkinson, M, Miller, K, Nichols, T, Robinson, E, Salimi-Khorshidi, G, Woolrich, M, Barch, D, Uǧurbil, K, Van Essen, D
Format: Journal article
Published: 2013
Description
Summary:Spontaneous fluctuations in activity in different parts of the brain can be used to study functional brain networks. We review the use of resting-state functional MRI (rfMRI) for the purpose of mapping the macroscopic functional connectome. After describing MRI acquisition and image-processing methods commonly used to generate data in a form amenable to connectomics network analysis, we discuss different approaches for estimating network structure from that data. Finally, we describe new possibilities resulting from the high-quality rfMRI data being generated by the Human Connectome Project and highlight some upcoming challenges in functional connectomics. © 2013 Elsevier Ltd.