Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. Although neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been re...

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Hlavní autoři: Tao, J, Hu, K, Chang, Q, Wu, H, Sherman, N, Martinowich, K, Klose, R, Schanen, C, Jaenisch, R, Wang, W, Sun, Y
Médium: Journal article
Jazyk:English
Vydáno: 2009

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