Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. Although neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been re...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Tao, J, Hu, K, Chang, Q, Wu, H, Sherman, N, Martinowich, K, Klose, R, Schanen, C, Jaenisch, R, Wang, W, Sun, Y
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2009

Những quyển sách tương tự

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
Bằng: Tao, Jifang, et al.
Được phát hành: (2009)

MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
Bằng: Annika Schmidt, et al.
Được phát hành: (2022-09-01)

MeCP2 and Chromatin Compartmentalization
Bằng: Annika Schmidt, et al.
Được phát hành: (2020-04-01)

Author Correction: Brain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin association
Bằng: Gilda Stefanelli, et al.
Được phát hành: (2021-05-01)

MeCP2 repression goes nonglobal
Bằng: Klose, R, et al.
Được phát hành: (2003)

MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex.
Bằng: Klose, R, et al.
Được phát hành: (2004)

Sex-Based Mhrt Methylation Chromatinizes MeCP2 in the Heart
Bằng: Harikrishnan K.N., et al.
Được phát hành: (2019-07-01)

Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity
Bằng: Katrina V. Good, et al.
Được phát hành: (2017-11-01)

Circadian cycle-dependent MeCP2 and brain chromatin changes.
Bằng: Alexia Martínez de Paz, et al.
Được phát hành: (2015-01-01)

Sequential chromatin immunoprecipitation to detect SUMOylated MeCP2 in neurons
Bằng: Tao Wu, et al.
Được phát hành: (2016-03-01)

MeCP2 binding to DNA depends upon hydration at methyl-CpG.
Bằng: Ho, K, et al.
Được phát hành: (2008)

Correction: Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes.
Bằng: PLOS ONE Staff
Được phát hành: (2015-01-01)

Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain
Bằng: Evan C. Rosenberg, et al.
Được phát hành: (2018-08-01)

The molecular basis of MeCP2 function in the brain
Bằng: Tillotson, R, et al.
Được phát hành: (2019)

MeCP2 links heterochromatin condensates and neurodevelopmental disease
Bằng: Li, Charles H, et al.
Được phát hành: (2021)

DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.
Bằng: Klose, R, et al.
Được phát hành: (2005)

Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders
Bằng: Xiangling Meng, et al.
Được phát hành: (2016-06-01)

Rett Syndrome and MECP2 Duplication Syndrome: Disorders of MeCP2 Dosage
Bằng: Collins BE, et al.
Được phát hành: (2022-11-01)

Genetic modifiers of MeCP2 function in Drosophila.
Bằng: Holly N Cukier, et al.
Được phát hành: (2008-09-01)

MeCP2-Related Diseases and Animal Models
Bằng: Chinelo D. Ezeonwuka, et al.
Được phát hành: (2014-01-01)

MeCP2_e2 partially compensates for lack of MeCP2_e1: A male case of Rett syndrome
Bằng: Ryo Takeguchi, et al.
Được phát hành: (2020-02-01)

Expression Pattern of the Rett Syndrome Gene MeCP2 in Primate Prefrontal Cortex
Bằng: Schahram Akbarian, et al.
Được phát hành: (2001-10-01)

MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions
Bằng: Francesco M Piccolo, et al.
Được phát hành: (2019-12-01)

MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function
Bằng: Sameer S Bajikar, et al.
Được phát hành: (2023-02-01)

Structural investigation of Rett-inducing MeCP2 mutations
Bằng: Ottavia Spiga, et al.
Được phát hành: (2019-03-01)

MeCP2 interacts with chromosomal microRNAs in brain
Bằng: Abdul Waheed Khan, et al.
Được phát hành: (2017-12-01)

Epigenetic Dysfunction of Neurodegenerative Diseases, MeCP2 and More
Bằng: Heh-In Im
Được phát hành: (2022-11-01)

MeCP2 and transcriptional control of eukaryotic gene expression
Bằng: Ghanan Bin Akhtar, et al.
Được phát hành: (2022-06-01)

MeCP2: The Genetic Driver of Rett Syndrome Epigenetics
Bằng: Katrina V. Good, et al.
Được phát hành: (2021-01-01)

The Molecular Functions of MeCP2 in Rett Syndrome Pathology
Bằng: Osman Sharifi, et al.
Được phát hành: (2021-04-01)

MeCP2 modulates gene expression pathways in astrocytes
Bằng: Yasui Dag H, et al.
Được phát hành: (2013-01-01)

MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.
Bằng: Mellén, M, et al.
Được phát hành: (2012)

Novel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes.
Bằng: Robby M Zachariah, et al.
Được phát hành: (2012-01-01)

Neuronal non-CG methylation is an essential target for MeCP2 function
Bằng: Tillotson, R, et al.
Được phát hành: (2021)

Direct homo- and hetero-interactions of MeCP2 and MBD2.
Bằng: Annette Becker, et al.
Được phát hành: (2013-01-01)

Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements.
Bằng: Carl O Olson, et al.
Được phát hành: (2014-01-01)

A critique of the hypothesis that CA repeats are primary targets of neuronal MeCP2
Bằng: Chhatbar, K, et al.
Được phát hành: (2022)

The Role of MeCP2 in Regulating Synaptic Plasticity in the Context of Stress and Depression
Bằng: Carla L. Sánchez-Lafuente, et al.
Được phát hành: (2022-02-01)

MeCP2 Deficiency in Neuroglia: New Progress in the Pathogenesis of Rett Syndrome
Bằng: Xu-Rui Jin, et al.
Được phát hành: (2017-10-01)

MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells
Bằng: Chunli Wang, et al.
Được phát hành: (2018-04-01)