The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo

Mutation of human microcephalin (MCPH1) causes autosomal recessive primary microcephaly, a developmental disorder characterized by reduced brain size. We identified mcphl, the Drosophila homolog of MCPH1, in a genetic screen for regulators of S-M cycles in the early embryo. Embryos of null mcph1 fem...

詳細記述

書誌詳細
主要な著者: Rickmyre, J, DasGupta, S, Ooi, D, Keel, J, Lee, E, Kirschner, M, Waddell, S, Lee, L
フォーマット: Journal article
言語:English
出版事項: 2007