Diabetes and risk of hospitalisation due to infection in northeastern Thailand: retrospective cohort study using population-based healthcare service data
<p><b>Background</b></p> Population-based studies describing the association between diabetes and increased risk of infection have largely been based in high-income countries. There is limited information describing the burden of infectious disease attributable to diabetes in...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2024
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| _version_ | 1811140488974041088 |
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| author | Peerawaranun, P Pan-ngum, W Hantrakun, V Wild, SH Dunachie, S Chamnan, P |
| author_facet | Peerawaranun, P Pan-ngum, W Hantrakun, V Wild, SH Dunachie, S Chamnan, P |
| author_sort | Peerawaranun, P |
| collection | OXFORD |
| description | <p><b>Background</b></p>
Population-based studies describing the association between diabetes and increased risk of infection have largely been based in high-income countries. There is limited information describing the burden of infectious disease attributable to diabetes in low and middle-income countries. This study aimed to describe the burden and risk of infectious disease hospitalisation in people with diabetes compared to those without diabetes in northeastern Thailand.
<p><b>Methods</b></p>
In a retrospective cohort study using electronic health record data for 2012–2018 for 3.8 million people aged ≥20 years in northeastern Thailand, hospitalisation rates for any infectious diseases (ICD-10 codes A00-B99) were estimated and negative binomial regression used to estimate rate ratios (RR) for the association between diabetes and infectious disease hospitalisation adjusted for age, sex and area of residence.
<p><b>Results</b></p>
In this study, 164,177 people had a diagnosis of diabetes mellitus at any point over the study period. Infectious disease hospitalisation rates per 1000 person-years (95%CI) were 71.8 (70.9, 72.8), 27.7 (27.1, 28.3) and 7.5 (7.5, 7.5) for people with prevalent diabetes, incident diabetes and those without diabetes respectively. Diabetes was associated with a 4.6-fold higher risk of infectious disease hospitalisation (RR (95% CI) 4.59 (4.52, 4.66)). RRs for infectious disease hospitalisation were 3.38 (3.29, 3.47) for people with diabetes managed by lifestyle alone and 5.29 (5.20, 5.39) for people receiving prescriptions for diabetes drugs.
<p><b>Conclusions</b></p>
In this Thai population, diabetes was associated with substantially increased risk of hospitalisation due to infectious diseases and people with diabetes who were on pharmacological treatment had a higher risk than those receiving lifestyle modification advice alone. |
| first_indexed | 2024-09-25T04:22:47Z |
| format | Journal article |
| id | oxford-uuid:d8724964-9b31-4ab2-8777-0422a78054fa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:22:47Z |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:d8724964-9b31-4ab2-8777-0422a78054fa2024-08-09T14:28:38ZDiabetes and risk of hospitalisation due to infection in northeastern Thailand: retrospective cohort study using population-based healthcare service dataJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d8724964-9b31-4ab2-8777-0422a78054faEnglishSymplectic ElementsWiley2024Peerawaranun, PPan-ngum, WHantrakun, VWild, SHDunachie, SChamnan, P<p><b>Background</b></p> Population-based studies describing the association between diabetes and increased risk of infection have largely been based in high-income countries. There is limited information describing the burden of infectious disease attributable to diabetes in low and middle-income countries. This study aimed to describe the burden and risk of infectious disease hospitalisation in people with diabetes compared to those without diabetes in northeastern Thailand. <p><b>Methods</b></p> In a retrospective cohort study using electronic health record data for 2012–2018 for 3.8 million people aged ≥20 years in northeastern Thailand, hospitalisation rates for any infectious diseases (ICD-10 codes A00-B99) were estimated and negative binomial regression used to estimate rate ratios (RR) for the association between diabetes and infectious disease hospitalisation adjusted for age, sex and area of residence. <p><b>Results</b></p> In this study, 164,177 people had a diagnosis of diabetes mellitus at any point over the study period. Infectious disease hospitalisation rates per 1000 person-years (95%CI) were 71.8 (70.9, 72.8), 27.7 (27.1, 28.3) and 7.5 (7.5, 7.5) for people with prevalent diabetes, incident diabetes and those without diabetes respectively. Diabetes was associated with a 4.6-fold higher risk of infectious disease hospitalisation (RR (95% CI) 4.59 (4.52, 4.66)). RRs for infectious disease hospitalisation were 3.38 (3.29, 3.47) for people with diabetes managed by lifestyle alone and 5.29 (5.20, 5.39) for people receiving prescriptions for diabetes drugs. <p><b>Conclusions</b></p> In this Thai population, diabetes was associated with substantially increased risk of hospitalisation due to infectious diseases and people with diabetes who were on pharmacological treatment had a higher risk than those receiving lifestyle modification advice alone. |
| spellingShingle | Peerawaranun, P Pan-ngum, W Hantrakun, V Wild, SH Dunachie, S Chamnan, P Diabetes and risk of hospitalisation due to infection in northeastern Thailand: retrospective cohort study using population-based healthcare service data |
| title | Diabetes and risk of hospitalisation due to infection in northeastern Thailand: retrospective cohort study using population-based healthcare service data |
| title_full | Diabetes and risk of hospitalisation due to infection in northeastern Thailand: retrospective cohort study using population-based healthcare service data |
| title_fullStr | Diabetes and risk of hospitalisation due to infection in northeastern Thailand: retrospective cohort study using population-based healthcare service data |
| title_full_unstemmed | Diabetes and risk of hospitalisation due to infection in northeastern Thailand: retrospective cohort study using population-based healthcare service data |
| title_short | Diabetes and risk of hospitalisation due to infection in northeastern Thailand: retrospective cohort study using population-based healthcare service data |
| title_sort | diabetes and risk of hospitalisation due to infection in northeastern thailand retrospective cohort study using population based healthcare service data |
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