Sequential catalytic functionalization of aryltriazenyl aldehydes for the synthesis of complex benzenes
We demonstrate that aryltriazenes can promote three distinctive types of C-H functionalization reactions, allowing the preparation of complex benzene molecules with diverse substitution patterns. 2-Triazenylbenzaldehydes are shown to be efficient substrates for Rh(I)-catalyzed...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2021
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| Summary: | We demonstrate that aryltriazenes can promote
three distinctive types of C-H functionalization reactions,
allowing the preparation of complex benzene molecules with
diverse substitution patterns. 2-Triazenylbenzaldehydes are
shown to be efficient substrates for Rh(I)-catalyzed
intermolecular alkyne hydroacylation reactions. The resulting
triazene-substituted ketone products can then undergo either
a Rh(III)-catalyzed C-H activation, or an electrophilic aromatic
substitution reaction, achieving multi-functionalization of the
benzene core. Subsequent triazene derivatization provides
traceless products |
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