Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria.
BACKGROUND: Plasmodium falciparum and Plasmodium vivax are co-endemic in the Asia-Pacific region. Their capacity to induce and sustain diverse T-cell responses underpins protective immunity. We compared T-cell responses to the largely conserved merozoite surface protein-5 (PfMSP5) during acute and c...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826299459630268416 |
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| author | Salwati, E Minigo, G Woodberry, T Piera, K de Silva, H Kenangalem, E Tjitra, E Coppel, R Price, R Anstey, N Plebanski, M |
| author_facet | Salwati, E Minigo, G Woodberry, T Piera, K de Silva, H Kenangalem, E Tjitra, E Coppel, R Price, R Anstey, N Plebanski, M |
| author_sort | Salwati, E |
| collection | OXFORD |
| description | BACKGROUND: Plasmodium falciparum and Plasmodium vivax are co-endemic in the Asia-Pacific region. Their capacity to induce and sustain diverse T-cell responses underpins protective immunity. We compared T-cell responses to the largely conserved merozoite surface protein-5 (PfMSP5) during acute and convalescent falciparum and vivax malaria. METHODS: Lymphoproliferation and IFN--γ secretion to PfMSP5 and purified protein derivate were quantified in adults with falciparum (n=34), and vivax malaria (n=12) or asymptomatic residents (n=10) of Papua, Indonesia. Responses were reassessed 7-28 days following treatment. RESULTS: The frequency of IFN-γ responders to PfMSP5 was similar in acute falciparum (63%) or vivax (67%) malaria. However, significantly more IFN-γ-secreting cells were detectable during vivax compared with falciparum infection. Purified protein derivative responses showed a similarly enhanced pattern. While rapidly lost in vivax patients, PfMSP5-specific responses in falciparum malaria remained to day 28. By contrast, frequency and magnitude of lymphoproliferation to PfMSP5 were similar for falciparum and vivax infections. CONCLUSION: Cellular PfMSP5-specific responses are most frequent during either acute falciparum or vivax malaria, indicating functional T-cell responses to conserved antigens. Both effector and central memory T-cell functions are increased. Greater IFN-γ responses in acute P. vivax, suggest enhancement of pre-existing effector T-cells during acute vivax infection. |
| first_indexed | 2024-03-07T05:02:15Z |
| format | Journal article |
| id | oxford-uuid:d8ae8fae-6f26-45e8-8d50-d476092306b6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:02:15Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:d8ae8fae-6f26-45e8-8d50-d476092306b62022-03-27T08:50:32ZDifferential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d8ae8fae-6f26-45e8-8d50-d476092306b6EnglishSymplectic Elements at Oxford2011Salwati, EMinigo, GWoodberry, TPiera, Kde Silva, HKenangalem, ETjitra, ECoppel, RPrice, RAnstey, NPlebanski, MBACKGROUND: Plasmodium falciparum and Plasmodium vivax are co-endemic in the Asia-Pacific region. Their capacity to induce and sustain diverse T-cell responses underpins protective immunity. We compared T-cell responses to the largely conserved merozoite surface protein-5 (PfMSP5) during acute and convalescent falciparum and vivax malaria. METHODS: Lymphoproliferation and IFN--γ secretion to PfMSP5 and purified protein derivate were quantified in adults with falciparum (n=34), and vivax malaria (n=12) or asymptomatic residents (n=10) of Papua, Indonesia. Responses were reassessed 7-28 days following treatment. RESULTS: The frequency of IFN-γ responders to PfMSP5 was similar in acute falciparum (63%) or vivax (67%) malaria. However, significantly more IFN-γ-secreting cells were detectable during vivax compared with falciparum infection. Purified protein derivative responses showed a similarly enhanced pattern. While rapidly lost in vivax patients, PfMSP5-specific responses in falciparum malaria remained to day 28. By contrast, frequency and magnitude of lymphoproliferation to PfMSP5 were similar for falciparum and vivax infections. CONCLUSION: Cellular PfMSP5-specific responses are most frequent during either acute falciparum or vivax malaria, indicating functional T-cell responses to conserved antigens. Both effector and central memory T-cell functions are increased. Greater IFN-γ responses in acute P. vivax, suggest enhancement of pre-existing effector T-cells during acute vivax infection. |
| spellingShingle | Salwati, E Minigo, G Woodberry, T Piera, K de Silva, H Kenangalem, E Tjitra, E Coppel, R Price, R Anstey, N Plebanski, M Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria. |
| title | Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria. |
| title_full | Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria. |
| title_fullStr | Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria. |
| title_full_unstemmed | Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria. |
| title_short | Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria. |
| title_sort | differential cellular recognition of antigens during acute plasmodium falciparum and plasmodium vivax malaria |
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