The role of IRAK3 in regulating immune-mediated inflammatory arthritis

The role of IRAK3 in regulating immune-mediated inflammatory arthritis

<p>A repeated or prolonged stimulation with LPS induces in macrophage-lineage cells a refractory state known as endotoxin tolerance (ET). ET curtails inflammation and prevents tissue damage caused by sustained immune activation in sepsis. TNFα is required for ET induction and it is hypothesiz...

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Bibliographic Details
Main Author:	Borghese, F
Other Authors:	Williams, R
Format:	Thesis
Published:	2018

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