Key matrix proteins within the pancreatic islet basement membrane are differentially digested during human islet isolation.
<p>Clinical islet transplantation achieves insulin independence in selected patients, yet current methods for extracting islets from their surrounding pancreatic matrix are suboptimal. The islet basement membrane (BM) influences islet function and survival, and is a critical marker of islet in...
Main Authors: | Cross, S, Vaughan, R, Willcox, A, McBride, A, Abraham, A, Han, B, Johnson, J, Maillard, E, Bateman, P, Ramracheya, R, Rorsman, O, Kadler, K, Dunne, M, Hughes, S, Johnson, P |
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Format: | Journal article |
Language: | English |
Published: |
Wiley
2016
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