Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

Erythroferrone (ERFE) is produced by erythroblasts in response to erythropoietin (EPO) and acts in the liver to prevent hepcidin stimulation by BMP6. Hepcidin suppression allows for the mobilization of iron to the bone marrow for the production of red blood cells. Aberrantly high circulating ERFE in...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Arezes, J, Foy, N, McHugh, K, Quinkert, D, Benard, S, Sawant, A, Frost, J, Armitage, A, Pasricha, S, Lim, P, Tam, M, Lavallie, E, Pittman, D, Cunningham, O, Lambert, M, Murphy, J, Draper, S, Jasuja, R, Drakesmith, A
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	American Society of Hematology 2020

Gelijkaardige items

Erythroferrone inhibits the induction of hepcidin by BMP6
door: Arezes, J, et al.
Gepubliceerd in: (2018)

Is the Role of Hepcidin and Erythroferrone in the Pathogenesis of Beta Thalassemia the Key to Developing Novel Treatment Strategies?
door: Tsz Yuen Au, et al.
Gepubliceerd in: (2022-09-01)

Regulation of hepcidin by erythropoiesis: The story so far.
door: Pasricha, S, et al.
Gepubliceerd in: (2016)

Erythroferrone: An Erythroid Regulator of Hepcidin and Iron Metabolism
door: Richard Coffey, et al.
Gepubliceerd in: (2018-04-01)

Erythroferrone and hepcidin levels in children with iron deficiency anemia
door: Ramazan Dulkadir, et al.
Gepubliceerd in: (2024-04-01)

Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait.
door: Jones, E, et al.
Gepubliceerd in: (2014)

Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia
door: Chloé Latour, et al.
Gepubliceerd in: (2017-01-01)

A Comprehensive Analysis of the Erythropoietin-erythroferrone-hepcidin Pathway in Hereditary Hemolytic Anemias
door: Annelies J. van Vuren, et al.
Gepubliceerd in: (2021-09-01)

Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics
door: Katarzyna Skrypnik, et al.
Gepubliceerd in: (2020-04-01)

The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry
door: Melanie Castro-Mollo, et al.
Gepubliceerd in: (2021-05-01)

Rapid growth is a dominant predictor Of hepcidin suppression and declining ferritin in Gambian infants
door: Armitage, A, et al.
Gepubliceerd in: (2019)

Hepcidin and erythroferrone response to 3 weeks of exposure to normobaric hypoxia at rest in trained cyclists
door: Kamila Płoszczyca, et al.
Gepubliceerd in: (2023-11-01)

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
door: Pasricha, S, et al.
Gepubliceerd in: (2017)

The diagnostic potential of the iron-regulatory hormone hepcidin
door: Armitage, A, et al.
Gepubliceerd in: (2019)

HEPCIDIN REGULATION IN MALARIA INFECTION
door: Spottiswoode, N, et al.
Gepubliceerd in: (2013)

The diagnostic potential of the iron-regulatory hormone hepcidin
door: Andrew E. Armitage, et al.
Gepubliceerd in: (2019-06-01)

The role of activins in hepcidin regulation during malaria
door: Spottiswoode, N, et al.
Gepubliceerd in: (2017)

Hepcidin screening to guide iron supplementation in African children
door: Pasricha, S, et al.
Gepubliceerd in: (2015)

Characterization of Erythroferrone in a Teleost Fish (Dicentrarchus labrax) With Two Functional Hepcidin Types: More Than an Erythroid Regulator
door: João V. Neves, et al.
Gepubliceerd in: (2022-04-01)

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
door: Sant-Rayn Pasricha, et al.
Gepubliceerd in: (2017-09-01)

Induced disruption of the iron-regulatory hormone hepcidin inhibits acute inflammatory hypoferremia
door: Armitage, A, et al.
Gepubliceerd in: (2016)

A Novel ALAS2 Missense Mutation in Two Brothers With Iron Overload and Associated Alterations in Serum Hepcidin/Erythroferrone Levels
door: Acaynne Lira Zidanes, et al.
Gepubliceerd in: (2020-11-01)

Decreased hepcidin levels are associated with low steady-state hemoglobin in children with sickle cell disease in Tanzania
door: Lee, N, et al.
Gepubliceerd in: (2018)

Hepcidin and the iron-infection axis.
door: Drakesmith, A, et al.
Gepubliceerd in: (2012)

Reply to: Hepcidin in malaria superinfection: can findings be translated to humans?
door: Portugal, S, et al.
Gepubliceerd in: (2011)

Expression of the iron hormone hepcidin distinguishes different types of anemia in African children.
door: Pasricha, SR, et al.
Gepubliceerd in: (2014)

Dynamics of Erythroferrone Response to Erythropoietin in Rats
door: Peng Xu, et al.
Gepubliceerd in: (2022-04-01)

Iron, anemia and hepcidin in malaria.
door: Spottiswoode, N, et al.
Gepubliceerd in: (2014)

Hepcidin regulation by innate immune and infectious stimuli.
door: Armitage, A, et al.
Gepubliceerd in: (2011)

Hepcidin regulation by innate immune and infectious stimuli
door: Armitage, A, et al.
Gepubliceerd in: (2011)

The effects of hypoxia-inducible factors-1α and -2α and erythroferrone on hepcidin in patients with chronic kidney disease stages 3–5 and renal anemia
door: Jianghuai Hong, et al.
Gepubliceerd in: (2022-05-01)

Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
door: Prentice, A, et al.
Gepubliceerd in: (2012)

Serum Hepcidin concentrations decline during pregnancy and may identify iron deficiency: Analysis of a longitudinal pregnancy cohort in The Gambia.
door: Bah, A, et al.
Gepubliceerd in: (2017)

Understanding iron homeostasis in MDS: the role of erythroferrone
door: Mohammed L. Abba, et al.
Gepubliceerd in: (2024-05-01)

Physical Training Increases Erythroferrone Levels in Men
door: Inga Dziembowska, et al.
Gepubliceerd in: (2021-11-01)

Expression of fluorescent tagged recombinant erythroferrone protein
door: Min Min Than, et al.
Gepubliceerd in: (2018-01-01)

Expression of the Iron Hormone Hepcidin Distinguishes Different Types of Anemia in African Children
door: Pasricha, S-R, et al.
Gepubliceerd in: (2014)

DIFFERENCES IN HEPCIDIN REGULATION DISTINGUISH MILD AND SEVERE PHENOTYPES OF E-BETA THALASSAEMIA
door: Jones, E, et al.
Gepubliceerd in: (2013)

HEPCIDIN REGULATION DURING ACUTE INFECTIONS
door: Armitage, A, et al.
Gepubliceerd in: (2013)

Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya
door: Atkinson, S, et al.
Gepubliceerd in: (2015)