Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

Erythroferrone (ERFE) is produced by erythroblasts in response to erythropoietin (EPO) and acts in the liver to prevent hepcidin stimulation by BMP6. Hepcidin suppression allows for the mobilization of iron to the bone marrow for the production of red blood cells. Aberrantly high circulating ERFE in...

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Detalhes bibliográficos
Main Authors: Arezes, J, Foy, N, McHugh, K, Quinkert, D, Benard, S, Sawant, A, Frost, J, Armitage, A, Pasricha, S, Lim, P, Tam, M, Lavallie, E, Pittman, D, Cunningham, O, Lambert, M, Murphy, J, Draper, S, Jasuja, R, Drakesmith, A
Formato: Journal article
Idioma:English
Publicado em: American Society of Hematology 2020

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