Fluorescence to highlight the urethra - a human cadaveric study
<p>Purpose: Urethral injury is a feared complication of surgeons performing transanal TME (TaTME) or abdomino-perineal excision (APE) procedures. Injury during TaTME occurs when the prostate is inadvertently mobilised or as a direct injury similar to the direct injury during the perineal disse...
| প্রধান লেখক: | , , , |
|---|---|
| বিন্যাস: | Journal article |
| প্রকাশিত: |
Spinger Verlag
2017
|
| _version_ | 1826299525936971776 |
|---|---|
| author | Barnes, T Penna, M Hompes, R Cunningham, C |
| author_facet | Barnes, T Penna, M Hompes, R Cunningham, C |
| author_sort | Barnes, T |
| collection | OXFORD |
| description | <p>Purpose: Urethral injury is a feared complication of surgeons performing transanal TME (TaTME) or abdomino-perineal excision (APE) procedures. Injury during TaTME occurs when the prostate is inadvertently mobilised or as a direct injury similar to the direct injury during the perineal dissection of APE procedures. This is a proof-in-principle study aiming to assess the feasibility of using ICG to fluoresce the urethra in human cadavers.</p> <p>Methods: Indocyanine green at varying doses was mixed with instillagel and infiltrated into the urethra of male human cadavers. The urethra was exposed through either a perineal incision or by mobilisation of the prostate during a TaTME dissection and fluorescence observed using a PINPOINT laparoscope (NOVADAQ). Brightness was assessed on the images using ImageJ (National Institute of Health).</p> <p>Results: Eight cadavers were included in the study. Fluorescence was visualised in the urethra in all 8 cadavers. Minimal dissection was required to obtain fluorescence trans-perineally. In one cadaver the urethra was demonstrated under fluorescence using a simulated TaTME with additional fluorescence also being observed in the prostate. There was no correlation between brightness and dosing.</p> <p>Conclusions: This novel proof of principle study demonstrates a simple way in which the urethra may be easily identified preventing it from injury during surgery.</p> |
| first_indexed | 2024-03-07T05:03:16Z |
| format | Journal article |
| id | oxford-uuid:d90a89dd-35fb-4c57-a7c3-07c707513b6e |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:03:16Z |
| publishDate | 2017 |
| publisher | Spinger Verlag |
| record_format | dspace |
| spelling | oxford-uuid:d90a89dd-35fb-4c57-a7c3-07c707513b6e2022-03-27T08:53:11ZFluorescence to highlight the urethra - a human cadaveric studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d90a89dd-35fb-4c57-a7c3-07c707513b6eSymplectic Elements at OxfordSpinger Verlag2017Barnes, TPenna, MHompes, RCunningham, C<p>Purpose: Urethral injury is a feared complication of surgeons performing transanal TME (TaTME) or abdomino-perineal excision (APE) procedures. Injury during TaTME occurs when the prostate is inadvertently mobilised or as a direct injury similar to the direct injury during the perineal dissection of APE procedures. This is a proof-in-principle study aiming to assess the feasibility of using ICG to fluoresce the urethra in human cadavers.</p> <p>Methods: Indocyanine green at varying doses was mixed with instillagel and infiltrated into the urethra of male human cadavers. The urethra was exposed through either a perineal incision or by mobilisation of the prostate during a TaTME dissection and fluorescence observed using a PINPOINT laparoscope (NOVADAQ). Brightness was assessed on the images using ImageJ (National Institute of Health).</p> <p>Results: Eight cadavers were included in the study. Fluorescence was visualised in the urethra in all 8 cadavers. Minimal dissection was required to obtain fluorescence trans-perineally. In one cadaver the urethra was demonstrated under fluorescence using a simulated TaTME with additional fluorescence also being observed in the prostate. There was no correlation between brightness and dosing.</p> <p>Conclusions: This novel proof of principle study demonstrates a simple way in which the urethra may be easily identified preventing it from injury during surgery.</p> |
| spellingShingle | Barnes, T Penna, M Hompes, R Cunningham, C Fluorescence to highlight the urethra - a human cadaveric study |
| title | Fluorescence to highlight the urethra - a human cadaveric study |
| title_full | Fluorescence to highlight the urethra - a human cadaveric study |
| title_fullStr | Fluorescence to highlight the urethra - a human cadaveric study |
| title_full_unstemmed | Fluorescence to highlight the urethra - a human cadaveric study |
| title_short | Fluorescence to highlight the urethra - a human cadaveric study |
| title_sort | fluorescence to highlight the urethra a human cadaveric study |
| work_keys_str_mv | AT barnest fluorescencetohighlighttheurethraahumancadavericstudy AT pennam fluorescencetohighlighttheurethraahumancadavericstudy AT hompesr fluorescencetohighlighttheurethraahumancadavericstudy AT cunninghamc fluorescencetohighlighttheurethraahumancadavericstudy |