The activities of various antimalarial drugs on Plasmodium falciparum isolates in Kilifi Kenya and studies on mechanisms of resistance

The activities of various antimalarial drugs on Plasmodium falciparum isolates in Kilifi Kenya and studies on mechanisms of resistance

<p>Drug resistance is a significant challenge in the fight against malaria. Importantly, reduced efficacy has been reported against artemether (ATM)/Lumefantrine (LM) (LM-ATM), amodiaquine (AQ)/artesunate (AS) (AQ-AS), two important combination treatment regimens in Africa, and against piperaq...

Fuld beskrivelse

Bibliografiske detaljer
Hovedforfatter:	Mwai, L
Andre forfattere:	Marsh, K
Format:	Thesis
Sprog:	English
Udgivet:	2011
Fag:	Clinical laboratory sciences Clinical microbiology Malaria Pharmacology Medical Sciences Biology Multidrug resistance Genetics (life sciences) Parasitology Public Health Genetics (medical sciences) Tropical medicine Infectious diseases Life Sciences Bioinformatics (life sciences)

Lignende værker

Identifying genetic determinants of impaired PfEMP1 export in Plasmodium falciparum-infected erythrocytes
af: Neal, AT
Udgivet: (2014)

Within-host evolution of HIV-1 and the analysis of transmissible diversity
af: English, SE
Udgivet: (2012)

Reproducing speech intervals in the sub-hundred millisecond (ms) range with a translocation in 7q31
af: Garcia-Bellido, P
Udgivet: (2013)

Study of platelet-mediated clumping adhesion phenotypes in Plasmodium falciparum malaria
af: Onyambu, F, et al.
Udgivet: (2015)

Accessing complex genomic variation in Plasmodium falciparum natural infections
af: Wendler, J
Udgivet: (2015)

Identifying causative elements within structural variants associated with developmental disorders
af: Boulding, H
Udgivet: (2013)

An analysis of non-coding RNAs in Plasmodium falciparum and their potential role in antigenic variation
af: Christodoulou, Z
Udgivet: (2012)

Identification of novel genes involved in brain abnormality syndromes using next generation sequencing
af: Howard, M, et al.
Udgivet: (2014)

Functional genomics of severe sepsis and septic shock
af: Radhakrishnan, J
Udgivet: (2013)

Pathogenic mycobacteria achieve cellular persistence via lipid-mediated inhibition of the Niemann-Pick disease type C pathway
af: Fineran, PD
Udgivet: (2014)

A method for the identification of biological pathways
af: Honti, F
Udgivet: (2014)

Cortical dynamics subserving visual apparent motion
af: Ahmed, B, et al.
Udgivet: (2008)

The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya
af: Atkinson, S, et al.
Udgivet: (2007)

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
af: Taylor, K, et al.
Udgivet: (2014)

The roles of the homeobox genes ALX4 and MSX2 in skull development
af: Mavrogiannis, L
Udgivet: (2004)

Enhancing the efficacy of viral vector blood-stage malaria vaccines
af: Forbes, E
Udgivet: (2011)

Morbidity and mortality due to Plasmodium vivax malaria in Papua, Indonesia and its control using antimalarial drugs
af: Douglas, N
Udgivet: (2011)

The genetics of handedness and dyslexia
af: Brandler, W
Udgivet: (2014)

Evaluation of strain circulation and the epidemiology of enteric fever caused
af: Karkey, A, et al.
Udgivet: (2012)

The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria
af: Medana, I, et al.
Udgivet: (2002)

Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12
af: Casals-Pascual, C, et al.
Udgivet: (2006)

Revisiting the design of phase III clinical trials of antimalarial drugs for uncomplicated Plasmodium falciparum malaria
af: Borrmann, S, et al.
Udgivet: (2008)

Intergenic long noncoding RNAs provide a novel layer of post-transcriptional regulation in development and disease
af: Tan, J
Udgivet: (2014)

Genetics of chronic otitis media: a mouse to man approach
af: Bhutta, M
Udgivet: (2012)

Probing the molecular basis of melanopsin induced light sensitivity
af: Vachtsevanos, AN
Udgivet: (2012)

Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi, Kenya
af: Akech, S, et al.
Udgivet: (2008)

Examining the relationship between genetic variation at G6PD and severe malaria
af: Shah, SS
Udgivet: (2011)

Clinical studies on enteric fever
af: Arjyal, A, et al.
Udgivet: (2014)

Prevalence of Staphylococcus aureus protein A (spa) mutants in the community and hospitals in Oxfordshire.
af: Votintseva, A, et al.
Udgivet: (2014)

On genetic variants underlying common disease
af: Hechter, E
Udgivet: (2011)

The analysis of homologous recombination pathways in Saccharomyces Cerevisiae
af: Tay, Y
Udgivet: (2010)

Elucidating the input of notch ligand delta-like 4 (dll4) in zebrafish blood stem cell ontogeny
af: Schneider, J, et al.
Udgivet: (2014)

A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes
af: Ogbadoyi, E, et al.
Udgivet: (2003)

Functional characterisation of a multiple sclerosis-associated genetic variant
af: Gregory, A
Udgivet: (2012)

Molecular mechanisms of recombination hotspots in humans
af: Noor, N
Udgivet: (2013)

Whole-genome analysis of the transcriptional network underlying male sexual behaviour in Drosophila melanogaster
af: Ashley, E, et al.
Udgivet: (2012)

Human population structure and demographic history using genetic markers
af: Wilson, J, et al.
Udgivet: (2002)

Germline determinants of 5-fluorouracil drug toxicity and patient survival in colorectal cancer
af: Rosmarin, DN
Udgivet: (2013)

Pathogen identification in lower respiratory tract infection
af: Wrightson, JM
Udgivet: (2014)

Human genetic resistance to malaria.
af: Williams, T
Udgivet: (2009)