Lung microbiome dynamics in COPD exacerbations

Lung microbiome dynamics in COPD exacerbations

Increasing evidence suggests that the lung microbiome plays an important role in chronic obstructive pulmonary disease (COPD) severity. However, the dynamics of the lung microbiome during COPD exacerbations and its potential role in disease aetiology remain poorly understood. We completed a longitud...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Wang, Z, Bafadhel, M, Haldar, K, Spivak, A, Mayhew, D, Miller, BE, Tal-Singer, R, Johnston, SL, Ramsheh, MY, Barer, MR, Brightling, CE, Brown, JR
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	European Respiratory Society 2016

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nork: Bafadhel, M, et al.
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COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils
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Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial.
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Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD
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Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease
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Altered gene expression in blood and sputum in COPD frequent exacerbators in the ECLIPSE cohort.
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