Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort.

Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort.

Recent genome-wide association studies have identified several loci that confer an increased risk of colorectal cancer (CRC). We studied the role of the 8q24.21 (rs6983267), 18q21.1 (rs12953717), 15q13.3 (rs4779584), 11q23.1 (rs3802842), 8q23.3 (rs16892766), and 10p14 (rs10795668) risk variants in a...

ver descrição completa

Detalhes bibliográficos
Principais autores:	Middeldorp, A, Jagmohan-Changur, S, van Eijk, R, Tops, C, Devilee, P, Vasen, H, Hes, F, Houlston, R, Tomlinson, I, Houwing-Duistermaat, J, Wijnen, J, Morreau, H, van Wezel, T
Formato:	Journal article
Idioma:	English
Publicado em:	2009

Registros relacionados

A procedure for the detection of linkage with high density SNP arrays in a large pedigree with colorectal cancer
por: Morreau Hans, et al.
Publicado em: (2007-01-01)

Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.
por: Wijnen, J, et al.
Publicado em: (2009)

Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas
por: Tops Carli MJ, et al.
Publicado em: (2009-06-01)

Chromosome 8q23.3, 10p14 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome – a combined analysis of the Australian, Dutch and Polish Lynch syndrome cohorts
por: Talseth-Palmer Bente A, et al.
Publicado em: (2012-04-01)

Fine Mapping of Colorectal Cancer Low Penetrance Susceptibility Loci
por: Carvajal-Carmona, L, et al.
Publicado em: (2009)

Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients.
por: Anne M L Jansen, et al.
Publicado em: (2016-01-01)

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
por: Niittymäki, I, et al.
Publicado em: (2011)

Detecting low penetrance genes in cancer: the way ahead.
por: Houlston, R, et al.
Publicado em: (2000)

Early onset MSI-H colon cancer with <it>MLH1 </it>promoter methylation, is there a genetic predisposition?
por: Hes Frederik J, et al.
Publicado em: (2010-05-01)

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci
por: Houlston Richard S, et al.
Publicado em: (2011-02-01)

Imputation as a method to fine map cancer susceptibility loci
por: Whiffin, N, et al.
Publicado em: (2012)

<it>MLPAinter for MLPA interpretation: </it>an integrated approach for the analysis, visualisation and data management of Multiplex Ligation-dependent Probe Amplification
por: Morreau Hans, et al.
Publicado em: (2010-01-01)

Improving stability of prediction models based on correlated omics data by using network approaches.
por: Renaud Tissier, et al.
Publicado em: (2018-01-01)

Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients
por: Diantha Terlouw, et al.
Publicado em: (2024-01-01)

L1 and L2 reading skills in Dutch adolescents with a familial risk of dyslexia
por: Ellie R.H. van Setten, et al.
Publicado em: (2017-10-01)

Assessment of global phase uncertainty in case-control studies
por: van Houwelingen Hans C, et al.
Publicado em: (2009-09-01)

Influence of genotyping error in linkage mapping for complex traits – an analytic study
por: van Houwelingen Hans C, et al.
Publicado em: (2008-08-01)

Treatment of penetrating trauma of the extremities: ten years’ experience at a dutch level 1 trauma center
por: Van Waes Oscar JF, et al.
Publicado em: (2013-01-01)

Beneficial Effects of the mTOR Inhibitor Everolimus in Patients with Advanced Medullary Thyroid Carcinoma: Subgroup Results of a Phase II Trial
por: T. C. Schneider, et al.
Publicado em: (2015-01-01)

A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort
por: J. A. M. Stolwijk, et al.
Publicado em: (2013-01-01)

Penetrance interactions of colour pattern loci in the African Monarch and their implications for the evolution of dominance
por: Richard H. ffrench‐Constant, et al.
Publicado em: (2024-02-01)

Cost-utility analysis of genetic screening in families of patients with germline <it>MUTYH </it>mutations
por: Vasen Hans FA, et al.
Publicado em: (2007-07-01)

The Dutch in New Netherland
por: H. van der Zee, et al.
Publicado em: (1982-01-01)

The Dutch in New Netherland
por: H. van der Zee, et al.
Publicado em: (1982-01-01)

The Dutch in New Netherland
por: H. van der Zee, et al.
Publicado em: (1982-01-01)

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.
por: Tomlinson, I, et al.
Publicado em: (2010)

A genetic variant in telomerase reverse transcriptase (TERT) modifies cancer risk in Lynch syndrome patients harbouring pathogenic MSH2 variants
por: Mariann Unhjem Wiik, et al.
Publicado em: (2021-05-01)

Penetration of Dutch Colonial Power Against the Sultanate of Jambi, 1615-1904
por: Budi Purnomo
Publicado em: (2020-06-01)

Genome-wide analysis in multiple-case families: assessing the relationship between triglyceride and methylation
por: Angga M. Fuady, et al.
Publicado em: (2018-09-01)

Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder – A multiplex multigenerational neuroimaging studyResearch in context
por: Janna Marie Bas-Hoogendam, et al.
Publicado em: (2018-10-01)

Evaluation of regression methods when immunological measurements are constrained by detection limits
por: Yazdanbakhsh Maria, et al.
Publicado em: (2008-10-01)

The first Dutch <it>SDHB </it>founder deletion in paraganglioma – pheochromocytoma patients
por: Devilee Peter, et al.
Publicado em: (2009-04-01)

Peutz-Jeghers syndrome.
por: Tomlinson, I, et al.
Publicado em: (1997)

Is EXO1 a colon cancer predisposition gene?
por: Tomlinson, I, et al.
Publicado em: (2001)

Modifier genes in humans: strategies for identification.
por: Houlston, R, et al.
Publicado em: (1998)

Polymorphisms and colorectal tumor risk.
por: Houlston, R, et al.
Publicado em: (2001)

Genetic prognostic markers in colorectal cancer.
por: Houlston, R, et al.
Publicado em: (1997)

Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci.
por: Reeves, G, et al.
Publicado em: (2010)

Methylation associated transcriptional repression of ELOVL5 in novel colorectal cancer cell lines.
por: Arnoud Boot, et al.
Publicado em: (2017-01-01)

The ideal of biopsychosocial chronic care: How to make it real? A qualitative study among Dutch stakeholders
por: van Dijk-de Vries Anneke, et al.
Publicado em: (2012-03-01)