IKZF1 deletions with COBL breakpoints are not driven by RAG-mediated recombination events in acute lymphoblastic leukemia

IKZF1 deletions with COBL breakpoints are not driven by RAG-mediated recombination events in acute lymphoblastic leukemia

IKZF1 deletion (ΔIKZF1) is an important predictor of relapse in both childhood and adult B-cell precursor acute lymphoblastic leukemia (B-ALL). Previously, we revealed that COBL is a hotspot for breakpoints in leukemia and could promote IKZF1 deletions. Through an international collaboration, we pro...

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Hlavní autoři: Lopes, BA, Meyer, C, Barbosa, TC, Poubel, CP, Braga Mansur, M, Duployez, N, Bashton, M, Harrison, CJ, Zur Stadt, U, Horstmann, M, Pombo-de-Oliveira, MS, Palmi, C, Cazzaniga, G, Venn, NC, Sutton, R, Alonso, CN, Tsaur, G, Gupta, SK, Bakhshi, S, Marschalek, R, Emerenciano, M
Médium: Journal article
Jazyk:English
Vydáno: Elsevier 2019

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