Burden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysis
<h4>Background</h4> <p>Childhood mortality from infectious diseases has declined steadily in many low and middle-income (LAMIC) countries, with increased recognition of non-communicable diseases such as neurodevelopmental disorders (NDD). There is lack of data on the burden of NDD...
| Автори: | , , , |
|---|---|
| Формат: | Journal article |
| Опубліковано: |
Wellcome Trust
2017
|
| _version_ | 1826299607272914944 |
|---|---|
| author | Bitta, M Kariuki, S Abubakar, A Newton, C |
| author_facet | Bitta, M Kariuki, S Abubakar, A Newton, C |
| author_sort | Bitta, M |
| collection | OXFORD |
| description | <h4>Background</h4> <p>Childhood mortality from infectious diseases has declined steadily in many low and middle-income (LAMIC) countries, with increased recognition of non-communicable diseases such as neurodevelopmental disorders (NDD). There is lack of data on the burden of NDD in LAMIC. Current global burden of these disorders are largely extrapolated from high-income countries. The main objective of the study was therefore to estimate the burden of NDD in LAMIC using meta-analytic techniques.</p> <h4>Methods</h4> <p>We systematically searched online databases including Medline/PubMed, PsychoInfo, and Embase for studies that reported prevalence or incidence of NDD. Pooled prevalence, heterogeneity and risk factors for prevalence were determined using meta-analytic techniques.</p> <h4>Results</h4> <p>We identified 4,802 records, but only 51 studies met the eligibility criteria. Most studies were from Asia (52.2%) and most were on neurological disorders (63.1%). The median pooled prevalence per 1,000 for all NDD was 7.6 (95%CI 7.5-7.7), being 11.3 (11.7-12.0) for neurological disorders and 3.2 (95%CI 3.1-3.3) for mental conditions such as attention-deficit hyperactivity disorder (ADHD). The type of NDD was significantly associated with the greatest prevalence ratio in the multivariable model (PR=2.6(95%CI 0.6-11.6) (P>0.05). Incidence was only reported for epilepsy (mean of 447.7 (95%CI 415.3-481.9) per 100,000). Perinatal complications were the commonest risk factor for NDD.</p> <h4>Conclusion</h4> <p>The burden of NDD in LAMIC is considerable. Epidemiological surveys on NDD should screen all types of NDD to provide reliable estimates.</p> |
| first_indexed | 2024-03-07T05:04:30Z |
| format | Journal article |
| id | oxford-uuid:d9747dc0-3686-4d38-ac8c-406b84f32fa7 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:04:30Z |
| publishDate | 2017 |
| publisher | Wellcome Trust |
| record_format | dspace |
| spelling | oxford-uuid:d9747dc0-3686-4d38-ac8c-406b84f32fa72022-03-27T08:56:00ZBurden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d9747dc0-3686-4d38-ac8c-406b84f32fa7Symplectic Elements at OxfordWellcome Trust2017Bitta, MKariuki, SAbubakar, ANewton, C <h4>Background</h4> <p>Childhood mortality from infectious diseases has declined steadily in many low and middle-income (LAMIC) countries, with increased recognition of non-communicable diseases such as neurodevelopmental disorders (NDD). There is lack of data on the burden of NDD in LAMIC. Current global burden of these disorders are largely extrapolated from high-income countries. The main objective of the study was therefore to estimate the burden of NDD in LAMIC using meta-analytic techniques.</p> <h4>Methods</h4> <p>We systematically searched online databases including Medline/PubMed, PsychoInfo, and Embase for studies that reported prevalence or incidence of NDD. Pooled prevalence, heterogeneity and risk factors for prevalence were determined using meta-analytic techniques.</p> <h4>Results</h4> <p>We identified 4,802 records, but only 51 studies met the eligibility criteria. Most studies were from Asia (52.2%) and most were on neurological disorders (63.1%). The median pooled prevalence per 1,000 for all NDD was 7.6 (95%CI 7.5-7.7), being 11.3 (11.7-12.0) for neurological disorders and 3.2 (95%CI 3.1-3.3) for mental conditions such as attention-deficit hyperactivity disorder (ADHD). The type of NDD was significantly associated with the greatest prevalence ratio in the multivariable model (PR=2.6(95%CI 0.6-11.6) (P>0.05). Incidence was only reported for epilepsy (mean of 447.7 (95%CI 415.3-481.9) per 100,000). Perinatal complications were the commonest risk factor for NDD.</p> <h4>Conclusion</h4> <p>The burden of NDD in LAMIC is considerable. Epidemiological surveys on NDD should screen all types of NDD to provide reliable estimates.</p> |
| spellingShingle | Bitta, M Kariuki, S Abubakar, A Newton, C Burden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysis |
| title | Burden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysis |
| title_full | Burden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysis |
| title_fullStr | Burden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysis |
| title_full_unstemmed | Burden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysis |
| title_short | Burden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysis |
| title_sort | burden of neurodevelopmental disorders in low and middle income countries a systematic review and meta analysis |
| work_keys_str_mv | AT bittam burdenofneurodevelopmentaldisordersinlowandmiddleincomecountriesasystematicreviewandmetaanalysis AT kariukis burdenofneurodevelopmentaldisordersinlowandmiddleincomecountriesasystematicreviewandmetaanalysis AT abubakara burdenofneurodevelopmentaldisordersinlowandmiddleincomecountriesasystematicreviewandmetaanalysis AT newtonc burdenofneurodevelopmentaldisordersinlowandmiddleincomecountriesasystematicreviewandmetaanalysis |