Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). Colibactin’s distinct mutational signature is reflected in human CRC, suggesting a causal link. Here, we investigate its transfor...
Main Authors: | Iftekhar, A, Berger, H, Bouznad, N, Heuberger, J, Boccellato, F, Dobrindt, U, Hermeking, H, Sigal, M, Meyer, TF |
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Format: | Journal article |
Language: | English |
Published: |
Nature Research
2021
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