Long micro-channel electrode arrays: a novel type of regenerative peripheral nerve interface.
We have demonstrated that micro-channel electrode arrays with 100 microm x 100 microm cross-section channels support axon regeneration well, and that micro-channels of similar calibre and up to 5 mm long can support axon regeneration and vascularisation. They may be microfabricated using silicon, si...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797098101797814272 |
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| author | Lacour, S Fitzgerald, J Lago, N Tarte, E McMahon, S Fawcett, J |
| author_facet | Lacour, S Fitzgerald, J Lago, N Tarte, E McMahon, S Fawcett, J |
| author_sort | Lacour, S |
| collection | OXFORD |
| description | We have demonstrated that micro-channel electrode arrays with 100 microm x 100 microm cross-section channels support axon regeneration well, and that micro-channels of similar calibre and up to 5 mm long can support axon regeneration and vascularisation. They may be microfabricated using silicon, silicone, or polyimide and thin metal films to form 3-D bundles of long micro-channels. Arrays of "mini-nerves," i.e., miniature nerve fascicles with their own blood vessels, successfully grew through implants 0.5-5 mm long. Furthermore, guiding the regenerating nerve fibres into the small insulating channels allows for a significant increase of the extracellular (recordable) amplitude of action potentials, which promises considerable improvement for in vivo electrophysiology. |
| first_indexed | 2024-03-07T05:04:50Z |
| format | Journal article |
| id | oxford-uuid:d991a835-2aa9-487b-ac85-ed0c4e3f211c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:04:50Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:d991a835-2aa9-487b-ac85-ed0c4e3f211c2022-03-27T08:56:47ZLong micro-channel electrode arrays: a novel type of regenerative peripheral nerve interface.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d991a835-2aa9-487b-ac85-ed0c4e3f211cEnglishSymplectic Elements at Oxford2009Lacour, SFitzgerald, JLago, NTarte, EMcMahon, SFawcett, JWe have demonstrated that micro-channel electrode arrays with 100 microm x 100 microm cross-section channels support axon regeneration well, and that micro-channels of similar calibre and up to 5 mm long can support axon regeneration and vascularisation. They may be microfabricated using silicon, silicone, or polyimide and thin metal films to form 3-D bundles of long micro-channels. Arrays of "mini-nerves," i.e., miniature nerve fascicles with their own blood vessels, successfully grew through implants 0.5-5 mm long. Furthermore, guiding the regenerating nerve fibres into the small insulating channels allows for a significant increase of the extracellular (recordable) amplitude of action potentials, which promises considerable improvement for in vivo electrophysiology. |
| spellingShingle | Lacour, S Fitzgerald, J Lago, N Tarte, E McMahon, S Fawcett, J Long micro-channel electrode arrays: a novel type of regenerative peripheral nerve interface. |
| title | Long micro-channel electrode arrays: a novel type of regenerative peripheral nerve interface. |
| title_full | Long micro-channel electrode arrays: a novel type of regenerative peripheral nerve interface. |
| title_fullStr | Long micro-channel electrode arrays: a novel type of regenerative peripheral nerve interface. |
| title_full_unstemmed | Long micro-channel electrode arrays: a novel type of regenerative peripheral nerve interface. |
| title_short | Long micro-channel electrode arrays: a novel type of regenerative peripheral nerve interface. |
| title_sort | long micro channel electrode arrays a novel type of regenerative peripheral nerve interface |
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