Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKALI and HHEX-IDE gene loci reduce birth weight

Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKALI and HHEX-IDE gene loci reduce birth weight

Manylion Llyfryddiaeth
Prif Awduron:	Hattersley, A, Freathy, R, Bennett, A, Ring, S, Timpson, N, Pouta, A, Ruokonen, A, Hypponen, E, Power, C, Elliott, P, Strachan, D, Jarvelin, M, Smith, G, McCarthy, M, Frayling, T
Fformat:	Conference item
Cyhoeddwyd:	2008

Eitemau Tebyg

Type 2 diabetes risk alleles are associated with reduced size at birth.
gan: Freathy, R, et al.
Cyhoeddwyd: (2009)

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
gan: Pascoe, L, et al.
Cyhoeddwyd: (2007)

Common variation in the FTO (fused toes) gene is strongly associated with adiposity measures in the northern finnish birth cohort of 1966
gan: Bennett, A, et al.
Cyhoeddwyd: (2007)

Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
gan: Freathy, R, et al.
Cyhoeddwyd: (2007)

Mutations in HHEX are not a common cause of monogenic forms of beta cell dysfunction.
gan: Minton, J, et al.
Cyhoeddwyd: (2007)

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable.
gan: Lawlor, D, et al.
Cyhoeddwyd: (2008)

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
gan: Lawlor, D, et al.
Cyhoeddwyd: (2008)

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
gan: Lawlor, D, et al.
Cyhoeddwyd: (2008)

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
gan: Freathy, R, et al.
Cyhoeddwyd: (2007)

Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.
gan: Bullock, J, et al.
Cyhoeddwyd: (2013)

Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease
gan: Bullock, J, et al.
Cyhoeddwyd: (2013)

Stratified analysis of the Wellcome Trust Case Control Consortium scan for type 2 diabetes reveals susceptibility loci that may affect age of diagnosis
gan: Fernandez-Cadenas, I, et al.
Cyhoeddwyd: (2008)

Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs
gan: M. Ruiz-Estevez, et al.
Cyhoeddwyd: (2021-05-01)

Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: a fine-mapping study in Chinese population.
gan: Yun Qian, et al.
Cyhoeddwyd: (2012-01-01)

The transcription factor Hhex regulates inflammation-related genes in microglia
gan: Risa Sakate, et al.
Cyhoeddwyd: (2022-07-01)

HHEX：a crosstalker between HCMV infection and proliferation of VSMCs
gan: Lingfang Li, et al.
Cyhoeddwyd: (2016-11-01)

Weight at birth and infancy in relation to adult leukocyte count: a population-based study of 5619 men and women followed from the fetal period to adulthood.
gan: Canoy, D, et al.
Cyhoeddwyd: (2009)

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
gan: Freathy, R, et al.
Cyhoeddwyd: (2008)

Extended analysis of genome-wide scans provides clues about novel common and rare susceptibility loci for type 2 diabetes
gan: Zeggini, E, et al.
Cyhoeddwyd: (2008)

Genome-wide search for multiple loci in type 2 diabetes
gan: Bell, J, et al.
Cyhoeddwyd: (2007)

HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.
gan: Hitoshi Watanabe, et al.
Cyhoeddwyd: (2014-01-01)

A powerful approach to sub-phenotype analysis in population-based genetic association studies.
gan: Morris, A, et al.
Cyhoeddwyd: (2010)

Adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort.
gan: Vääräsmäki, M, et al.
Cyhoeddwyd: (2009)

Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2.
gan: Weedon, M, et al.
Cyhoeddwyd: (2003)

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
gan: Groves, C, et al.
Cyhoeddwyd: (2003)

Exploring the developmental overnutrition hypothesis using parental-offspring associations and the FTO gene as an instrumental variable for maternal adiposity. The Avon Longitudinal Study of Parents And Children (ALSPAC)
gan: Lawlor, D, et al.
Cyhoeddwyd: (2007)

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
gan: Frayling, T, et al.
Cyhoeddwyd: (2003)

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
gan: Freathy, R, et al.
Cyhoeddwyd: (2006)

Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance
gan: Wilford Goh, et al.
Cyhoeddwyd: (2020-10-01)

Association between the HHEX polymorphism and delayed memory in first-episode schizophrenic patients
gan: Zhen Hua Zhu, et al.
Cyhoeddwyd: (2024-06-01)

Clinicopathological Significances of Cancer Stem Cell-Associated HHEX Expression in Breast Cancer
gan: Kexin Zhang, et al.
Cyhoeddwyd: (2020-12-01)

Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in MiceSummary
gan: Mark J. Ferreira, et al.
Cyhoeddwyd: (2015-09-01)

Manifestations of metabolic syndrome after hypertensive pregnancy.
gan: Pouta, A, et al.
Cyhoeddwyd: (2004)

Maternal gestational diabetes and the manifestations of metabolic syndrome in adolescent offspring
gan: Pouta, A, et al.
Cyhoeddwyd: (2006)

No evidence that established type 2 diabetes susceptibility variants in the PPARG and KCNJ11 genes have pleiotropic effects on early growth.
gan: Bennett, A, et al.
Cyhoeddwyd: (2008)

A Mendelian randomisation study provides initial evidence that sex hormone binding globulin (SHBG) levels alter type 2 diabetes risk
gan: Perry, J, et al.
Cyhoeddwyd: (2008)

The fat mass- and obesity-associated locus and dietary intake in children.
gan: Timpson, N, et al.
Cyhoeddwyd: (2008)

Hhex Is Necessary for the Hepatic Differentiation of Mouse ES Cells and Acts via Vegf Signaling.
gan: Adam S Arterbery, et al.
Cyhoeddwyd: (2016-01-01)

Genome-wide association scan allowing for epistasis in type 2 diabetes.
gan: Bell, J, et al.
Cyhoeddwyd: (2011)

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
gan: Frayling, T, et al.
Cyhoeddwyd: (2000)