Network meta-analyses in child and adolescent psychiatry: a meta-review
<strong>Objectives</strong> Network meta-analyses (NMAs) are gaining traction as the preferred method for evidence synthesis of intervention studies. This review aimed to summarize the basics of NMAs and conduct a meta-review of available NMAs on the treatment of child and adolescent psy...
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| Format: | Journal article |
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Elsevier
2018
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| _version_ | 1826299635634798592 |
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| author | Cortese, S Tomlinson, A Cipriani, A |
| author_facet | Cortese, S Tomlinson, A Cipriani, A |
| author_sort | Cortese, S |
| collection | OXFORD |
| description | <strong>Objectives</strong> Network meta-analyses (NMAs) are gaining traction as the preferred method for evidence synthesis of intervention studies. This review aimed to summarize the basics of NMAs and conduct a meta-review of available NMAs on the treatment of child and adolescent psychiatric disorders by appraising their quality. <strong>Method</strong> PubMed (Medline), PsycInfo, Embase, Ovid Medline, and Web of Knowledge were systematically searched (last update January 9, 2018). The quality of each included NMA was appraised using the AMSTAR-2 tool and the PRISMA-NMA checklist, which include specific items for NMAs. <strong>Results</strong> Eighteen NMAs (6 on attention-deficit/hyperactivity disorder; 4 on psychotic disorders; 2 on depression; 2 on anxiety disorders; 1 on obsessive compulsive disorder; 1 on disruptive behavior disorder, 1 on bipolar disorder, and 1 on antipsychotics across disorders) were retrieved. Results from the AMSTAR-2 assessment showed that only 27% of appraised NMAs were rated as moderate quality; most were rated as low (33%) or critically low (40%) quality. Only 3 of the appraised NMAs reported on all PRISMA-NMA items specific for NMAs; the network structure was graphically presented in most NMAs (80%), and inconsistency was described in only 47%. <strong>Conclusion</strong> Given the paucity of head-to-head trials in child and adolescent psychiatry, NMAs have the potential to contribute to the field, because they provide evidence-based hierarchies for treatment decision making, even in the absence of trials directly comparing at least 2 treatments. However, because of important limitations in the included NMAs, additional methodologically sound NMAs are needed to inform future guidelines and clinical practice in child and adolescent psychiatry. |
| first_indexed | 2024-03-07T05:04:57Z |
| format | Journal article |
| id | oxford-uuid:d99a4fdf-740b-46f8-ba66-ab94fdf29b83 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:04:57Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:d99a4fdf-740b-46f8-ba66-ab94fdf29b832022-03-27T08:57:02ZNetwork meta-analyses in child and adolescent psychiatry: a meta-reviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d99a4fdf-740b-46f8-ba66-ab94fdf29b83Symplectic Elements at OxfordElsevier2018Cortese, STomlinson, ACipriani, A<strong>Objectives</strong> Network meta-analyses (NMAs) are gaining traction as the preferred method for evidence synthesis of intervention studies. This review aimed to summarize the basics of NMAs and conduct a meta-review of available NMAs on the treatment of child and adolescent psychiatric disorders by appraising their quality. <strong>Method</strong> PubMed (Medline), PsycInfo, Embase, Ovid Medline, and Web of Knowledge were systematically searched (last update January 9, 2018). The quality of each included NMA was appraised using the AMSTAR-2 tool and the PRISMA-NMA checklist, which include specific items for NMAs. <strong>Results</strong> Eighteen NMAs (6 on attention-deficit/hyperactivity disorder; 4 on psychotic disorders; 2 on depression; 2 on anxiety disorders; 1 on obsessive compulsive disorder; 1 on disruptive behavior disorder, 1 on bipolar disorder, and 1 on antipsychotics across disorders) were retrieved. Results from the AMSTAR-2 assessment showed that only 27% of appraised NMAs were rated as moderate quality; most were rated as low (33%) or critically low (40%) quality. Only 3 of the appraised NMAs reported on all PRISMA-NMA items specific for NMAs; the network structure was graphically presented in most NMAs (80%), and inconsistency was described in only 47%. <strong>Conclusion</strong> Given the paucity of head-to-head trials in child and adolescent psychiatry, NMAs have the potential to contribute to the field, because they provide evidence-based hierarchies for treatment decision making, even in the absence of trials directly comparing at least 2 treatments. However, because of important limitations in the included NMAs, additional methodologically sound NMAs are needed to inform future guidelines and clinical practice in child and adolescent psychiatry. |
| spellingShingle | Cortese, S Tomlinson, A Cipriani, A Network meta-analyses in child and adolescent psychiatry: a meta-review |
| title | Network meta-analyses in child and adolescent psychiatry: a meta-review |
| title_full | Network meta-analyses in child and adolescent psychiatry: a meta-review |
| title_fullStr | Network meta-analyses in child and adolescent psychiatry: a meta-review |
| title_full_unstemmed | Network meta-analyses in child and adolescent psychiatry: a meta-review |
| title_short | Network meta-analyses in child and adolescent psychiatry: a meta-review |
| title_sort | network meta analyses in child and adolescent psychiatry a meta review |
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