Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.

Mammalian cells possess mechanisms to detect and defend themselves from invading viruses. In the cytosol, the RIG-I-like receptors (RLRs), RIG-I (retinoic acid-inducible gene I; encoded by DDX58) and MDA5 (melanoma differentiation-associated gene 5; encoded by IFIH1) sense atypical RNAs associated w...

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Bibliographic Details
Main Authors: Goubau, D, Schlee, M, Deddouche, S, Pruijssers, A, Zillinger, T, Goldeck, M, Schuberth, C, Van der Veen, A, Fujimura, T, Rehwinkel, J, Iskarpatyoti, J, Barchet, W, Ludwig, J, Dermody, T, Hartmann, G, Reis e Sousa, C
Format: Journal article
Language:English
Published: Nature Publishing Group 2014

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