The epidemic behavior of the hepatitis C virus.
Hepatitis C virus (HCV) is a leading worldwide cause of liver disease. Here, we use a new model of HCV spread to investigate the epidemic behavior of the virus and to estimate its basic reproductive number from gene sequence data. We find significant differences in epidemic behavior among HCV subtyp...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1826299655348027392 |
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| author | Pybus, O Charleston, M Gupta, S Rambaut, A Holmes, E Harvey, P |
| author_facet | Pybus, O Charleston, M Gupta, S Rambaut, A Holmes, E Harvey, P |
| author_sort | Pybus, O |
| collection | OXFORD |
| description | Hepatitis C virus (HCV) is a leading worldwide cause of liver disease. Here, we use a new model of HCV spread to investigate the epidemic behavior of the virus and to estimate its basic reproductive number from gene sequence data. We find significant differences in epidemic behavior among HCV subtypes and suggest that these differences are largely the result of subtype-specific transmission patterns. Our model builds a bridge between the disciplines of population genetics and mathematical epidemiology by using pathogen gene sequences to infer the population dynamic history of an infectious disease. |
| first_indexed | 2024-03-07T05:05:15Z |
| format | Journal article |
| id | oxford-uuid:d9b4492c-6528-4b42-9dff-0aaa1598d4f2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:05:15Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:d9b4492c-6528-4b42-9dff-0aaa1598d4f22022-03-27T08:57:52ZThe epidemic behavior of the hepatitis C virus.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d9b4492c-6528-4b42-9dff-0aaa1598d4f2EnglishSymplectic Elements at Oxford2001Pybus, OCharleston, MGupta, SRambaut, AHolmes, EHarvey, PHepatitis C virus (HCV) is a leading worldwide cause of liver disease. Here, we use a new model of HCV spread to investigate the epidemic behavior of the virus and to estimate its basic reproductive number from gene sequence data. We find significant differences in epidemic behavior among HCV subtypes and suggest that these differences are largely the result of subtype-specific transmission patterns. Our model builds a bridge between the disciplines of population genetics and mathematical epidemiology by using pathogen gene sequences to infer the population dynamic history of an infectious disease. |
| spellingShingle | Pybus, O Charleston, M Gupta, S Rambaut, A Holmes, E Harvey, P The epidemic behavior of the hepatitis C virus. |
| title | The epidemic behavior of the hepatitis C virus. |
| title_full | The epidemic behavior of the hepatitis C virus. |
| title_fullStr | The epidemic behavior of the hepatitis C virus. |
| title_full_unstemmed | The epidemic behavior of the hepatitis C virus. |
| title_short | The epidemic behavior of the hepatitis C virus. |
| title_sort | epidemic behavior of the hepatitis c virus |
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