Oxazolidinone antibiotics impair ex vivo megakaryocyte differentiation from hematopoietic progenitor cells and their maturation into platelets

Oxazolidinone antibiotics impair ex vivo megakaryocyte differentiation from hematopoietic progenitor cells and their maturation into platelets

Oxazolidinones (linezolid and tedizolid) adverse reactions include thrombocytopenia, the mechanism of which is still largely unknown. In cultured cells, oxazolidinones impair mitochondrial protein synthesis and oxidative metabolism. As mitochondrial activity is essential for megakaryocyte differenti...

Bibliografiset tiedot
Päätekijät:	Milosevic, TV, Vertenoeil, G, Vainchenker, W, Tulkens, PM, Constantinescu, SN, Van Bambeke, F
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	American Society for Microbiology 2024

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