A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
Conditional expression of diphtheria toxin receptor (DTR) is widely used for tissue-specific ablation of cells. However, diphtheria toxin (DT) crosses the blood–brain barrier, which limits its utility for ablating peripheral cells using Cre drivers that are also expressed in the central nervous syst...
Main Authors: | Pereira, M, Mahú, I, Seixas, E, Martinéz-Sánchez, N, Kubasova, N, Pirzgalska, R, Cohen, P, Dietrich, M, López, M, Bernardes, G, Domingos, A |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Springer Nature
2017
|
Similar Items
-
Protective monoclonal antibodies to diphtheria toxin
by: Maria das Graças M. Danelli, et al.
Published: (1991-06-01) -
Effect of the T-domain on intracellular transport of diphtheria toxin
by: А. J. Labyntsev, et al.
Published: (2014-06-01) -
Effect of diphtheria toxin T-domain on endosomal pH
by: A. J. Labyntsev, et al.
Published: (2015-08-01) -
Insights into Diphthamide, Key Diphtheria Toxin Effector
by: Raffael Schaffrath, et al.
Published: (2013-05-01) -
Sensitivity of cancer cells to truncated diphtheria toxin.
by: Yi Zhang, et al.
Published: (2010-05-01)