Non-linear and flexible regions of the human Notch-1 extracellular domain revealed by high-resolution structural studies
The Notch receptor is a key component of a core metazoan signalling pathway activated by Delta/Serrate/Lag-2 ligands expressed on an adjacent cell. This results in a short-range signal with profound effects on cell-fate determination, cell proliferation and cell death. Key to understanding receptor...
| Principais autores: | , , , , , , |
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| Formato: | Journal article |
| Publicado em: |
Cell Press
2016
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