Xpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a small step forward
The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis sugg...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2020
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| _version_ | 1797110119656325120 |
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| author | Donovan, J Cresswell, FV Thuong, NTT Boulware, DR Thwaites, GE Bahr, NC Tuberculous Meningitis International Research Consortium |
| author_facet | Donovan, J Cresswell, FV Thuong, NTT Boulware, DR Thwaites, GE Bahr, NC Tuberculous Meningitis International Research Consortium |
| author_sort | Donovan, J |
| collection | OXFORD |
| description | The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis suggested increased sensitivity of Xpert Ultra. Two subsequent studies have shown Xpert Ultra has improved sensitivity, but has insufficient negative predictive value to exclude TBM. Collecting and processing large volumes of CSF for mycobacterial testing are important for optimal diagnostic test performance. But clinical, radiological, and laboratory parameters remain essential for TBM diagnosis and empiric therapy is often needed. We therefore caution against the use of Xpert Ultra as a single diagnostic test for TBM; it cannot be used to “rule out” TBM. |
| first_indexed | 2024-03-07T07:50:38Z |
| format | Journal article |
| id | oxford-uuid:d9de2e15-cc68-4076-98e8-24c9d6ecd600 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:50:38Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:d9de2e15-cc68-4076-98e8-24c9d6ecd6002023-07-06T09:44:25ZXpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a small step forwardJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d9de2e15-cc68-4076-98e8-24c9d6ecd600EnglishSymplectic ElementsOxford University Press2020Donovan, JCresswell, FVThuong, NTTBoulware, DRThwaites, GEBahr, NCTuberculous Meningitis International Research ConsortiumThe delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis suggested increased sensitivity of Xpert Ultra. Two subsequent studies have shown Xpert Ultra has improved sensitivity, but has insufficient negative predictive value to exclude TBM. Collecting and processing large volumes of CSF for mycobacterial testing are important for optimal diagnostic test performance. But clinical, radiological, and laboratory parameters remain essential for TBM diagnosis and empiric therapy is often needed. We therefore caution against the use of Xpert Ultra as a single diagnostic test for TBM; it cannot be used to “rule out” TBM. |
| spellingShingle | Donovan, J Cresswell, FV Thuong, NTT Boulware, DR Thwaites, GE Bahr, NC Tuberculous Meningitis International Research Consortium Xpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a small step forward |
| title | Xpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a small step forward |
| title_full | Xpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a small step forward |
| title_fullStr | Xpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a small step forward |
| title_full_unstemmed | Xpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a small step forward |
| title_short | Xpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a small step forward |
| title_sort | xpert mtb rif ultra for the diagnosis of tuberculous meningitis a small step forward |
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