Regulatory B cells in transplantation: roadmaps to clinic
Over the last two decades, an additional and important role for B cells has been established in immune regulation. Preclinical studies demonstrate that regulatory B cells (Breg) can prolong allograft survival in animal models and induce regulatory T cells. Operationally tolerant human kidney transpl...
| Príomhchruthaitheoirí: | , , , |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
Wiley
2020
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| _version_ | 1826299715385294848 |
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| author | Beckett, J Hester, J Issa, F Shankar, S |
| author_facet | Beckett, J Hester, J Issa, F Shankar, S |
| author_sort | Beckett, J |
| collection | OXFORD |
| description | Over the last two decades, an additional and important role for B cells has been established in immune regulation. Preclinical studies demonstrate that regulatory B cells (Breg) can prolong allograft survival in animal models and induce regulatory T cells. Operationally tolerant human kidney transplant recipients demonstrate B‐cell‐associated gene signatures of immune tolerance, and novel therapeutic agents can induce Bregs in phase I clinical trials in transplantation. Our rapidly expanding appreciation of this novel B‐cell subtype has made the road to clinical application a reality. Here, we outline several translational pathways by which Bregs could soon be introduced to the transplant clinic.
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| first_indexed | 2024-03-07T05:06:10Z |
| format | Journal article |
| id | oxford-uuid:d9ff5f4a-b7cd-48c9-bb6c-aae7362dc89c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:06:10Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:d9ff5f4a-b7cd-48c9-bb6c-aae7362dc89c2022-03-27T09:00:06ZRegulatory B cells in transplantation: roadmaps to clinicJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d9ff5f4a-b7cd-48c9-bb6c-aae7362dc89cEnglishSymplectic ElementsWiley2020Beckett, JHester, JIssa, FShankar, SOver the last two decades, an additional and important role for B cells has been established in immune regulation. Preclinical studies demonstrate that regulatory B cells (Breg) can prolong allograft survival in animal models and induce regulatory T cells. Operationally tolerant human kidney transplant recipients demonstrate B‐cell‐associated gene signatures of immune tolerance, and novel therapeutic agents can induce Bregs in phase I clinical trials in transplantation. Our rapidly expanding appreciation of this novel B‐cell subtype has made the road to clinical application a reality. Here, we outline several translational pathways by which Bregs could soon be introduced to the transplant clinic. |
| spellingShingle | Beckett, J Hester, J Issa, F Shankar, S Regulatory B cells in transplantation: roadmaps to clinic |
| title | Regulatory B cells in transplantation: roadmaps to clinic |
| title_full | Regulatory B cells in transplantation: roadmaps to clinic |
| title_fullStr | Regulatory B cells in transplantation: roadmaps to clinic |
| title_full_unstemmed | Regulatory B cells in transplantation: roadmaps to clinic |
| title_short | Regulatory B cells in transplantation: roadmaps to clinic |
| title_sort | regulatory b cells in transplantation roadmaps to clinic |
| work_keys_str_mv | AT beckettj regulatorybcellsintransplantationroadmapstoclinic AT hesterj regulatorybcellsintransplantationroadmapstoclinic AT issaf regulatorybcellsintransplantationroadmapstoclinic AT shankars regulatorybcellsintransplantationroadmapstoclinic |