Paternal age effect mutations in germ cell development: pathological correlates in normal testis and testicular tumours

<p>Pathogenic gain-of-function mutations associated with increased paternal age, albeit harmful to embryonic development, are paradoxically enriched in the normal testis. Evidence from previous studies indicates that these so-called paternal age-effect mutations confer a proliferative advantag...

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Manylion Llyfryddiaeth
Prif Awdur: Lim, J
Awduron Eraill: Wilkie, A
Fformat: Traethawd Ymchwil
Iaith:English
Cyhoeddwyd: 2011
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