Deep brain stimulation in multiple system atrophy mimicking idiopathic Parkinson's disease.
Deep brain stimulation (DBS) is approved for idiopathic Parkinson's disease (IPD) but has a poor evidence base in Parkinson-plus syndromes such as multiple system atrophy (MSA). We describe the clinical and neuropathological findings in a man who was initially diagnosed with IPD, in whom DBS wa...
| Autors principals: | , , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
Karger
2014
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| _version_ | 1826299745529757696 |
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| author | Thavanesan, N Gillies, M Farrell, M Green, A Aziz, T |
| author_facet | Thavanesan, N Gillies, M Farrell, M Green, A Aziz, T |
| author_sort | Thavanesan, N |
| collection | OXFORD |
| description | Deep brain stimulation (DBS) is approved for idiopathic Parkinson's disease (IPD) but has a poor evidence base in Parkinson-plus syndromes such as multiple system atrophy (MSA). We describe the clinical and neuropathological findings in a man who was initially diagnosed with IPD, in whom DBS was unsuccessful, and in whom MSA was unexpectedly diagnosed at a subsequent autopsy. This case report highlights that DBS is often unsuccessful in MSA and also demonstrates that MSA can masquerade as IPD, which may explain treatment failure in a small group of patients apparently suffering from Parkinson's disease. Additionally, it also presents a case with an unusually long duration of disease prior to death, comparable only to a handful of other cases in the literature. |
| first_indexed | 2024-03-07T05:06:36Z |
| format | Journal article |
| id | oxford-uuid:da23f5f5-c79f-4e8d-9d56-cfce621bb16a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:06:36Z |
| publishDate | 2014 |
| publisher | Karger |
| record_format | dspace |
| spelling | oxford-uuid:da23f5f5-c79f-4e8d-9d56-cfce621bb16a2022-03-27T09:01:00ZDeep brain stimulation in multiple system atrophy mimicking idiopathic Parkinson's disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:da23f5f5-c79f-4e8d-9d56-cfce621bb16aEnglishSymplectic Elements at OxfordKarger2014Thavanesan, NGillies, MFarrell, MGreen, AAziz, TDeep brain stimulation (DBS) is approved for idiopathic Parkinson's disease (IPD) but has a poor evidence base in Parkinson-plus syndromes such as multiple system atrophy (MSA). We describe the clinical and neuropathological findings in a man who was initially diagnosed with IPD, in whom DBS was unsuccessful, and in whom MSA was unexpectedly diagnosed at a subsequent autopsy. This case report highlights that DBS is often unsuccessful in MSA and also demonstrates that MSA can masquerade as IPD, which may explain treatment failure in a small group of patients apparently suffering from Parkinson's disease. Additionally, it also presents a case with an unusually long duration of disease prior to death, comparable only to a handful of other cases in the literature. |
| spellingShingle | Thavanesan, N Gillies, M Farrell, M Green, A Aziz, T Deep brain stimulation in multiple system atrophy mimicking idiopathic Parkinson's disease. |
| title | Deep brain stimulation in multiple system atrophy mimicking idiopathic Parkinson's disease. |
| title_full | Deep brain stimulation in multiple system atrophy mimicking idiopathic Parkinson's disease. |
| title_fullStr | Deep brain stimulation in multiple system atrophy mimicking idiopathic Parkinson's disease. |
| title_full_unstemmed | Deep brain stimulation in multiple system atrophy mimicking idiopathic Parkinson's disease. |
| title_short | Deep brain stimulation in multiple system atrophy mimicking idiopathic Parkinson's disease. |
| title_sort | deep brain stimulation in multiple system atrophy mimicking idiopathic parkinson s disease |
| work_keys_str_mv | AT thavanesann deepbrainstimulationinmultiplesystematrophymimickingidiopathicparkinsonsdisease AT gilliesm deepbrainstimulationinmultiplesystematrophymimickingidiopathicparkinsonsdisease AT farrellm deepbrainstimulationinmultiplesystematrophymimickingidiopathicparkinsonsdisease AT greena deepbrainstimulationinmultiplesystematrophymimickingidiopathicparkinsonsdisease AT azizt deepbrainstimulationinmultiplesystematrophymimickingidiopathicparkinsonsdisease |