BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair.
Following irradiation, numerous DNA-damage-responsive proteins rapidly redistribute into microscopically visible subnuclear aggregates, termed ionising-radiation-induced foci (IRIF). How the enrichment of proteins on damaged chromatin actually relates to DNA repair remains unclear. Here, we use supe...
Main Authors: | Chapman, R, Sossick, A, Boulton, S, Jackson, S |
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Format: | Journal article |
Language: | English |
Published: |
2012
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