Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.

Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.

The transmission disequilibrium test with use of trios (an affected proband with both parents) is a robust method for assessing the role of gene variants in disease that avoids the problem of population stratification that may confound conventional case/control studies and allows the detection of pa...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Frayling, T, Walker, M, McCarthy, M, Evans, J, Allen, L, Lynn, S, Ayres, S, Millauer, B, Turner, C, Turner, R, Sampson, M, Hitman, G, Ellard, S, Hattersley, A
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	1999

Antzeko izenburuak

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
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Assessing genuine parents-offspring trios for genetic association studies.
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Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes.
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Reduced beta cell function in offspring of mothers with young onset type 2 diabetes
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INCREASED INSULIN CONCENTRATIONS IN NONDIABETIC OFFSPRING OF DIABETIC PARENTS
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Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable.
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Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
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Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
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Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
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Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
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Type 2 diabetes and the human homolog of the rat insulin resistance gene, CD36: No linkage or association in Europeans
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Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
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No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
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Common variation in the LMNA gene increases susceptibility to type 2 diabetes
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Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
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Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
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Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
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No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
nork: Frayling, T, et al.
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Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
nork: Wiltshire, S, et al.
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A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
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Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls.
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Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.
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The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
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Large-scale association studies of candidate genes and their interactions in Type 2 diabetes
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Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
nork: Zeggini, E, et al.
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Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.
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Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
nork: Patel, S, et al.
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Maternal gestational diabetes and the manifestations of metabolic syndrome in adolescent offspring
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Genome-wide search for multiple loci in type 2 diabetes
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Concentration of plasma sialic acid in the offspring of one type II diabetic parent
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A note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test.
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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
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Exploring the developmental overnutrition hypothesis using parental-offspring associations and the FTO gene as an instrumental variable for maternal adiposity. The Avon Longitudinal Study of Parents And Children (ALSPAC)
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Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
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Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
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Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
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Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus
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