Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.

Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.

The transmission disequilibrium test with use of trios (an affected proband with both parents) is a robust method for assessing the role of gene variants in disease that avoids the problem of population stratification that may confound conventional case/control studies and allows the detection of pa...

Bibliografiset tiedot
Päätekijät:	Frayling, T, Walker, M, McCarthy, M, Evans, J, Allen, L, Lynn, S, Ayres, S, Millauer, B, Turner, C, Turner, R, Sampson, M, Hitman, G, Ellard, S, Hattersley, A
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	1999

Samankaltaisia teoksia

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
Tekijä: Huxtable, S, et al.
Julkaistu: (2000)

Assessing genuine parents-offspring trios for genetic association studies.
Tekijä: Teo, Y, et al.
Julkaistu: (2009)

Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes.
Tekijä: Singh, R, et al.
Julkaistu: (2006)

Reduced beta cell function in offspring of mothers with young onset type 2 diabetes
Tekijä: Singh, R, et al.
Julkaistu: (2005)

INCREASED INSULIN CONCENTRATIONS IN NONDIABETIC OFFSPRING OF DIABETIC PARENTS
Tekijä: Orahilly, S, et al.
Julkaistu: (1989)

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable.
Tekijä: Lawlor, D, et al.
Julkaistu: (2008)

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
Tekijä: Lawlor, D, et al.
Julkaistu: (2008)

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
Tekijä: Lawlor, D, et al.
Julkaistu: (2008)

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
Tekijä: Owen, K, et al.
Julkaistu: (2004)

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
Tekijä: Frayling, T, et al.
Julkaistu: (2003)

Type 2 diabetes and the human homolog of the rat insulin resistance gene, CD36: No linkage or association in Europeans
Tekijä: McCarthy, M, et al.
Julkaistu: (1999)

Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach
Tekijä: Gloyn, A, et al.
Julkaistu: (2005)

Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
Tekijä: Edghill, E, et al.
Julkaistu: (2011)

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
Tekijä: Weedon, M, et al.
Julkaistu: (2006)

Common variation in the LMNA gene increases susceptibility to type 2 diabetes
Tekijä: Owen, K, et al.
Julkaistu: (2006)

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
Tekijä: Zeggini, E, et al.
Julkaistu: (2005)

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
Tekijä: Freathy, R, et al.
Julkaistu: (2006)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Tekijä: Gloyn, A, et al.
Julkaistu: (2003)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
Tekijä: Gloyn, A, et al.
Julkaistu: (2003)

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
Tekijä: Frayling, T, et al.
Julkaistu: (2000)

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
Tekijä: Wiltshire, S, et al.
Julkaistu: (2004)

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
Tekijä: Weedon, M, et al.
Julkaistu: (2005)

Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls.
Tekijä: Chinnery, P, et al.
Julkaistu: (2007)

Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.
Tekijä: Mills, G, et al.
Julkaistu: (2004)

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
Tekijä: Freathy, R, et al.
Julkaistu: (2006)

Large-scale association studies of candidate genes and their interactions in Type 2 diabetes
Tekijä: Zeggini, E, et al.
Julkaistu: (2004)

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
Tekijä: Zeggini, E, et al.
Julkaistu: (2004)

Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.
Tekijä: Gloyn, A, et al.
Julkaistu: (2006)

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
Tekijä: Patel, S, et al.
Julkaistu: (2006)

Maternal gestational diabetes and the manifestations of metabolic syndrome in adolescent offspring
Tekijä: Pouta, A, et al.
Julkaistu: (2006)

Genome-wide search for multiple loci in type 2 diabetes
Tekijä: Bell, J, et al.
Julkaistu: (2007)

Concentration of plasma sialic acid in the offspring of one type II diabetic parent
Tekijä: Ismail, I.S., et al.
Julkaistu: (2001)

A note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test.
Tekijä: Evans, D, et al.
Julkaistu: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
Tekijä: Weedon, M, et al.
Julkaistu: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
Tekijä: Weedon, M, et al.
Julkaistu: (2006)

Exploring the developmental overnutrition hypothesis using parental-offspring associations and the FTO gene as an instrumental variable for maternal adiposity. The Avon Longitudinal Study of Parents And Children (ALSPAC)
Tekijä: Lawlor, D, et al.
Julkaistu: (2007)

Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
Tekijä: Wiltshire, S, et al.
Julkaistu: (2002)

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
Tekijä: Weedon, M, et al.
Julkaistu: (2004)

Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
Tekijä: Freathy, R, et al.
Julkaistu: (2007)

Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus
Tekijä: Qvist, R., et al.
Julkaistu: (2005)