Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.

The DYX2 locus on chromosome 6p22.2 is the most replicated region of linkage to developmental dyslexia (DD). Two candidate genes within this region have recently been implicated in the disorder: KIAA0319 and DCDC2. Variants within DCDC2 have shown association with DD in a US and a German sample. How...

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Asıl Yazarlar: Harold, D, Paracchini, S, Scerri, T, Dennis, M, Cope, N, Hill, G, Moskvina, V, Walter, J, Richardson, A, Owen, M, Stein, J, Green, E, O'Donovan, M, Williams, J, Monaco, A
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 2006
_version_ 1826299769961578496
author Harold, D
Paracchini, S
Scerri, T
Dennis, M
Cope, N
Hill, G
Moskvina, V
Walter, J
Richardson, A
Owen, M
Stein, J
Green, E
O'Donovan, M
Williams, J
Monaco, A
author_facet Harold, D
Paracchini, S
Scerri, T
Dennis, M
Cope, N
Hill, G
Moskvina, V
Walter, J
Richardson, A
Owen, M
Stein, J
Green, E
O'Donovan, M
Williams, J
Monaco, A
author_sort Harold, D
collection OXFORD
description The DYX2 locus on chromosome 6p22.2 is the most replicated region of linkage to developmental dyslexia (DD). Two candidate genes within this region have recently been implicated in the disorder: KIAA0319 and DCDC2. Variants within DCDC2 have shown association with DD in a US and a German sample. However, when we genotyped these specific variants in two large, independent UK samples, we obtained only weak, inconsistent evidence for their involvement in DD. Having previously found evidence that variation in the KIAA0319 gene confers susceptibility to DD, we sought to refine this genetic association by genotyping 36 additional SNPs in the gene. Nine SNPs, predominantly clustered around the first exon, showed the most significant association with DD in one or both UK samples, including rs3212236 in the 5' flanking region (P = 0.00003) and rs761100 in intron 1 (P = 0.0004). We have thus refined the region of association with developmental dyslexia to putative regulatory sequences around the first exon of the KIAA0319 gene, supporting the presence of functional mutations that could affect gene expression. Our data also suggests a possible interaction between KIAA0319 and DCDC2, which requires further testing.
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spelling oxford-uuid:da42af33-41e4-4fc9-a831-a5b49fb68de72022-03-27T09:02:03ZFurther evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:da42af33-41e4-4fc9-a831-a5b49fb68de7EnglishSymplectic Elements at Oxford2006Harold, DParacchini, SScerri, TDennis, MCope, NHill, GMoskvina, VWalter, JRichardson, AOwen, MStein, JGreen, EO'Donovan, MWilliams, JMonaco, AThe DYX2 locus on chromosome 6p22.2 is the most replicated region of linkage to developmental dyslexia (DD). Two candidate genes within this region have recently been implicated in the disorder: KIAA0319 and DCDC2. Variants within DCDC2 have shown association with DD in a US and a German sample. However, when we genotyped these specific variants in two large, independent UK samples, we obtained only weak, inconsistent evidence for their involvement in DD. Having previously found evidence that variation in the KIAA0319 gene confers susceptibility to DD, we sought to refine this genetic association by genotyping 36 additional SNPs in the gene. Nine SNPs, predominantly clustered around the first exon, showed the most significant association with DD in one or both UK samples, including rs3212236 in the 5' flanking region (P = 0.00003) and rs761100 in intron 1 (P = 0.0004). We have thus refined the region of association with developmental dyslexia to putative regulatory sequences around the first exon of the KIAA0319 gene, supporting the presence of functional mutations that could affect gene expression. Our data also suggests a possible interaction between KIAA0319 and DCDC2, which requires further testing.
spellingShingle Harold, D
Paracchini, S
Scerri, T
Dennis, M
Cope, N
Hill, G
Moskvina, V
Walter, J
Richardson, A
Owen, M
Stein, J
Green, E
O'Donovan, M
Williams, J
Monaco, A
Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.
title Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.
title_full Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.
title_fullStr Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.
title_full_unstemmed Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.
title_short Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.
title_sort further evidence that the kiaa0319 gene confers susceptibility to developmental dyslexia
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