Frequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients.
It has been hypothesized that too much synchronization in the beta band in basal ganglia-cortical circuits can contribute to bradykinesia and too little can contribute to hyperkinesia. The former has been supported by experiments in patients with Parkinson's disease and chronic implantation of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2009
|
| _version_ | 1826299770352697344 |
|---|---|
| author | Kühn, A Fogelson, N Limousin, P Hariz, M Kupsch, A Brown, P |
| author_facet | Kühn, A Fogelson, N Limousin, P Hariz, M Kupsch, A Brown, P |
| author_sort | Kühn, A |
| collection | OXFORD |
| description | It has been hypothesized that too much synchronization in the beta band in basal ganglia-cortical circuits can contribute to bradykinesia and too little can contribute to hyperkinesia. The former has been supported by experiments in patients with Parkinson's disease and chronic implantation of the subthalamic area for deep brain stimulation. Stimulation at 20 Hz in this region slows voluntary tapping when performed in patients withdrawn from their usual antiparkinsonian medication. Here, we show the converse, that stimulation of the same region at 20 Hz in patients treated with levodopa decreases the interval between taps by 8.1+/-1.8% and makes tapping more regular. We suggest that this effect is mediated through an amelioration of levodopa-induced dyskinesias during stimulation. |
| first_indexed | 2024-03-07T05:07:00Z |
| format | Journal article |
| id | oxford-uuid:da43328e-4564-4706-a9a6-cafb31f0cd45 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:07:00Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:da43328e-4564-4706-a9a6-cafb31f0cd452022-03-27T09:01:57ZFrequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:da43328e-4564-4706-a9a6-cafb31f0cd45EnglishSymplectic Elements at Oxford2009Kühn, AFogelson, NLimousin, PHariz, MKupsch, ABrown, PIt has been hypothesized that too much synchronization in the beta band in basal ganglia-cortical circuits can contribute to bradykinesia and too little can contribute to hyperkinesia. The former has been supported by experiments in patients with Parkinson's disease and chronic implantation of the subthalamic area for deep brain stimulation. Stimulation at 20 Hz in this region slows voluntary tapping when performed in patients withdrawn from their usual antiparkinsonian medication. Here, we show the converse, that stimulation of the same region at 20 Hz in patients treated with levodopa decreases the interval between taps by 8.1+/-1.8% and makes tapping more regular. We suggest that this effect is mediated through an amelioration of levodopa-induced dyskinesias during stimulation. |
| spellingShingle | Kühn, A Fogelson, N Limousin, P Hariz, M Kupsch, A Brown, P Frequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients. |
| title | Frequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients. |
| title_full | Frequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients. |
| title_fullStr | Frequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients. |
| title_full_unstemmed | Frequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients. |
| title_short | Frequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients. |
| title_sort | frequency specific effects of stimulation of the subthalamic area in treated parkinson s disease patients |
| work_keys_str_mv | AT kuhna frequencyspecificeffectsofstimulationofthesubthalamicareaintreatedparkinsonsdiseasepatients AT fogelsonn frequencyspecificeffectsofstimulationofthesubthalamicareaintreatedparkinsonsdiseasepatients AT limousinp frequencyspecificeffectsofstimulationofthesubthalamicareaintreatedparkinsonsdiseasepatients AT harizm frequencyspecificeffectsofstimulationofthesubthalamicareaintreatedparkinsonsdiseasepatients AT kupscha frequencyspecificeffectsofstimulationofthesubthalamicareaintreatedparkinsonsdiseasepatients AT brownp frequencyspecificeffectsofstimulationofthesubthalamicareaintreatedparkinsonsdiseasepatients |